LitCovid-sentences  

PMC:7755033 / 249-2040 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes Abstract
T7 9-146 Sentence denotes Coronaviruses are etiological agents of extreme human and animal infection resulting in abnormalities primarily in the respiratory tract.
T8 147-285 Sentence denotes Presently, there is no defined COVID-19 intervention and clinical trials of prospective therapeutic agents are still in the nascent stage.
T9 286-366 Sentence denotes Withania somnifera (L.) Dunal (WS), is an important medicinal plant in Ayurveda.
T10 367-553 Sentence denotes The present study aimed to evaluate the antiviral potential of selected WS phytoconstituents against the novel SARS-CoV-2 target proteins and human ACE2 receptor using in silico methods.
T11 554-709 Sentence denotes Most of the phytoconstituents displayed good absorption and transport kinetics and were also found to display no associated mutagenic or adverse effect(s).
T12 710-921 Sentence denotes Molecular docking analyses revealed that most of the WS phytoconstituents exhibited potent binding to human ACE2 receptor, SAR-CoV and SARS-CoV-2 spike glycoproteins as well as the two main SARS-CoV-2 proteases.
T13 922-1016 Sentence denotes Most of the phytoconstituents were predicted to undergo Phase-I metabolism prior to excretion.
T14 1017-1133 Sentence denotes All phytoconstituents had favorable bioactivity scores with respect to various receptor proteins and target enzymes.
T15 1134-1281 Sentence denotes SAR analysis revealed that the number of oxygen atoms in the withanolide backbone and structural rearrangements were crucial for effective binding.
T16 1282-1535 Sentence denotes Molecular simulation analyses of SARS-CoV-2 spike protein and papain-like protease with Withanolides A and B, respectively, displayed a stability profile at 300 K and constant RMSDs of protein side chains and Cα atoms throughout the simulation run time.
T17 1536-1756 Sentence denotes In a nutshell, WS phytoconstituents warrant further investigations in vitro and in vivo to unravel their molecular mechanism(s) and modes of action for their future development as novel antiviral agents against COVID-19.
T18 1757-1785 Sentence denotes Communicated by Ramaswamy H.
T19 1786-1791 Sentence denotes Sarma