| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T152 |
0-6 |
Sentence |
denotes |
2.2.3. |
| T153 |
8-20 |
Sentence |
denotes |
Ghose filter |
| T154 |
21-166 |
Sentence |
denotes |
Receptor binding, cellular uptake and bioavailability of drug molecules is strongly influenced by molecular lipophilicity and molar refractivity. |
| T155 |
167-417 |
Sentence |
denotes |
Both of them signify hydrophobic and dispersive (van der Waals) interactions (Ghose & Crippen, 1987) of a drug molecule and are employed in 3D-QSAR studies to evaluate the drug-like character of molecules under study (Viswanadhan et al., 1990, 1991). |
| T156 |
418-576 |
Sentence |
denotes |
The following are the qualifying parameters for a putative drug candidate as per Ghose filter:clogP range between -0.4 and 5.6, with an average value of 2.52; |
| T157 |
577-636 |
Sentence |
denotes |
MW range between 160 and 480, with an average value of 357; |
| T158 |
637-710 |
Sentence |
denotes |
Molar refractivity range between 40 and 130, with an average value of 97; |
| T159 |
711-780 |
Sentence |
denotes |
Total number of atoms between 20 and 70, with an average value of 48. |
| T160 |
781-953 |
Sentence |
denotes |
The above parameters should be kept in mind for testing hypothetically proposed compounds before any in vitro and in vivo experimentation (Ghose, 1987; Ghose et al., 1999). |
