LitCovid-sentences  

PMC:7736111 / 97027-98703 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T572 0-148 Sentence denotes This detrimental relation of antibody response with poor disease outcome was also prevalent in the previous SARS-CoV infection (Zhang et al., 2006).
T573 149-394 Sentence denotes In a study on the sera samples obtained from SARS-CoV infected patients, a faster S protein-specific antibody response was found in patients who did not survive (14.7 days), as compared with the patients who recovered from the disease (20 days).
T574 395-527 Sentence denotes Further, the antibody titer was significantly higher in the deceased patients with faster production than in the recovered patients.
T575 528-719 Sentence denotes To mechanistically understand why antibody response has a more detrimental effect than protective, Liu et al. (2019) studied viral antibody response in animal models (Chinese rhesus monkeys).
T576 720-889 Sentence denotes When animals infected with the SARS-CoV and adoptively transferred with anti-S protein IgG could not prevent the infection but instead displayed severe disease symptoms.
T577 890-1087 Sentence denotes Presence of the S protein antibody abrogated wound healing, induced macrophage/monocyte infiltration into the lungs and caused the release of proinflammatory cytokine followed by acute lung injury.
T578 1088-1254 Sentence denotes This study thus demonstrated that the presence of S protein-specific antibody might have a deleterious effect in inducing lung injury, irrespective of the viral load.
T579 1255-1386 Sentence denotes However, since mechanistic details are difficult to discern in clinical samples, more studies in animal models need to be explored.
T580 1387-1676 Sentence denotes Further, owing to the dynamics of antibody response in clinical samples concerning underlying disease condition, age, and genetic factors; animal models will provide a cleaner system to delineate the antibody dynamics with respect to disease severity (Guan et al., 2020; Hou et al., 2020).