| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T509 |
0-189 |
Sentence |
denotes |
Further, it appears that unlike CD4+ T cells, the activation status of CD8+ T cells is more pronounced, which may account for their relatively faster exhaustion state (Wherry et al., 2007). |
| T510 |
190-398 |
Sentence |
denotes |
Interestingly, by studying the CD8+T cell response in convalescent patients, Habel et al. (2020) found that these cells skewed toward naïve, stem cell and central memory phenotypes, with low effector T cells. |
| T511 |
399-515 |
Sentence |
denotes |
While comparing the response with Influenza A viruses, SARS-CoV-2 directed CD8+ T exhibit relatively lower response. |
| T512 |
516-858 |
Sentence |
denotes |
Others have also shown a significant decline in CD8+ T cell subsets (naïve, effector, and memory) in COVID-19 patients, with a more pronounced decline in critical (n = 3) than severe (n = 5), and mild (n = 4), suggesting their robust activation during early disease followed by exhaustion during the critical condition (Wang W. et al., 2020). |
| T513 |
859-979 |
Sentence |
denotes |
On the contrary, CD4+ T cells were higher in the mild and critical cases than severe cases and healthy control (n = 12). |
| T514 |
980-1209 |
Sentence |
denotes |
These results imply that the overall T cell response is heterogenous, while CD8+ response, though robust during infection and correlates with the disease severity; but the response may not be long-lasting, at least in some cases. |
