| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T503 |
153-290 |
Sentence |
denotes |
These activated T cells are further recruited at the sites of infection (initially lungs) in the presence of their respective chemokines. |
| T504 |
291-508 |
Sentence |
denotes |
The activated CD4+ T cells are marked by the presence of cytokines like IFN-γ, IL-2, IL-12, IL-6, and GM-CSF, whereas activated CD8+T (cytotoxic T cells) are marked by the secretion of granzymes, perforins, and IFN-γ. |
| T505 |
509-837 |
Sentence |
denotes |
During SARS-CoV-2 infection, activated CD8+T cells exhibiting increased expression of granzyme A, B, and K (GZM-B, GZM-A, and GZM-K) were found in the lungs (Liao et al., 2020; Song et al., 2020; Zheng M. et al., 2020). (B) T cells were also found to exhibit exhausted state as marked by the expression of PD-1, Tim3, and NKG2A. |
| T506 |
838-1104 |
Sentence |
denotes |
However, most studies showing exhausted T cells were confined to the peripheral blood, while lungs were mostly shown to have activated T cells but with concomitant expression of some exhaustive markers, suggesting that the activation state is followed by exhaustion. |
| T507 |
1105-1477 |
Sentence |
denotes |
The exhaustive T cells are marked by the reduced expression of respective chemokines and cytolytic granules. (C) Similarly, antibody-producing B cells (plasmablasts; PB) were shown to exhibit activation status as reflected by the expression of IL4R, TNFSF13B, and XBP1, while at the same time, the exhausted status of these cells was also reported in the peripheral blood. |
| T508 |
1478-1556 |
Sentence |
denotes |
Exhaustive state of B cells is reflected by a decrease in antibody production. |
