| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T286 |
0-27 |
Sentence |
denotes |
Proinflammatory neutrophils |
| T287 |
28-257 |
Sentence |
denotes |
Like other innate immune cells, neutrophils are protective in the early phases of infection by neutralizing the viral particles and release of protective molecules to interfere with the viral propagation (Drescher and Bai, 2013). |
| T288 |
258-395 |
Sentence |
denotes |
However, in severe cases, the number of these cells increases at the sites of infection and they become the leading damage-causing cells. |
| T289 |
396-646 |
Sentence |
denotes |
Excessive infiltration of these cells in the lungs is associated with secretion of TNF-α, IL-6, IL-1β, IL-7, IL-23, and IL-36, along with a broad range of other cytokines and damage-causing neutrophil extracellular traps (NETs; Tecchio et al., 2014). |
| T290 |
647-826 |
Sentence |
denotes |
Additionally, these neutrophils also secrete a range of chemokines like CCL2/3/4, CXCL1-13 to attract more neutrophils and monocytes from the circulation (Sokol and Luster, 2015). |
| T291 |
827-916 |
Sentence |
denotes |
Emerging evidence suggests a pivotal role of neutrophils in the pathogenesis of COVID-19. |
| T292 |
917-1131 |
Sentence |
denotes |
Immune cell profiling revealed activated status of these cells which was associated with increased levels of NETs and correlated with acute-phase reaction (Chen G. et al., 2020; Qin et al., 2020; Zuo et al., 2020). |
| T293 |
1132-1279 |
Sentence |
denotes |
Similarly, an increase in the number of activated neutrophils was present in the BALF of COVID-19 patients (Liao et al., 2020; Xiong et al., 2020). |
| T294 |
1280-1442 |
Sentence |
denotes |
Thus, based on these recently published studies, the neutrophil number in the blood can be used as a predictive marker for disease severity (Zhang et al., 2020a). |
