| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T268 |
0-164 |
Sentence |
denotes |
In addition to the secretion of DAMPs, AM and virus infected ATII cells secrete a range of pro-inflammatory molecules (Hussell and Bell, 2014; Glaser et al., 2019). |
| T269 |
165-363 |
Sentence |
denotes |
Among these, increased IL-6 levels are consistently detected in cultured cells infected with SARS-CoV and SARS-CoV-2 (Ye et al., 2018; Herold et al., 2020; Liu J. et al., 2020; Liu T. et al., 2020). |
| T270 |
364-622 |
Sentence |
denotes |
Notably, levels of TNF-α, IL-8, IL-10, GM-CSF, CXCL10, and CCL5 secreted by infected ATII and activated AMs were also consistently shown to increase during SARS-CoV and SARS-CoV-2 infections (Ward et al., 2005; Huang C. et al., 2020; Patterson et al., 2020). |
| T271 |
623-945 |
Sentence |
denotes |
Transcriptional profiling of cytokines and chemokines in normal human lung epithelial cells (NHBE) infected with SARS-CoV-2 revealed increased levels of CCL20, CXCL1, IL-1B, IL-6, CXCL3, CXCL5, CXCL6, CXCL2, CXCL16, and TNF-α by primary lung epithelial cells in response to SARS-CoV-2 infection (Blanco-Melo et al., 2020). |
| T272 |
946-1097 |
Sentence |
denotes |
Thus, lung resident ATII and AM cells besides being integral to the antiviral response also participate in generating a profound proinflammatory state. |
