| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T222 |
0-200 |
Sentence |
denotes |
Previous studies have unequivocally demonstrated poor IFN response to SARS-CoV during severe infection, which is also apparently the case with SARS-CoV-2, reviewed recently by Park and Iwasaki (2020). |
| T223 |
201-346 |
Sentence |
denotes |
In vitro culture of the primary lung, epithelial cells infected with the SARS-CoV-2 generated inadequate IFN response (Blanco-Melo et al., 2020). |
| T224 |
347-483 |
Sentence |
denotes |
By looking at the clinical samples, a large body of data suggests impaired IFN signaling in severe and critically ill COVID-19 patients. |
| T225 |
484-715 |
Sentence |
denotes |
Blood analysis from across the studies reveals low or undetectable levels of IFN-β and IFN-λ levels in patients exhibiting severe disease symptoms or patients admitted to the ICU with in a critical condition (Hadjadj et al., 2020). |
| T226 |
716-855 |
Sentence |
denotes |
Of note, an elegant study was conducted to explore the functional role of IFN signaling during various stages of COVID-19 disease severity. |
| T227 |
856-1000 |
Sentence |
denotes |
The study found robust impairment of IFN signaling in critically ill and severe patients in comparison to mild/moderate and healthy individuals. |
| T228 |
1001-1193 |
Sentence |
denotes |
IFN-β mRNA and protein were undetectable in all patients, whereas IFN-α2 protein was highly reduced in the plasma of severe and critically ill patients, corroborated with reduced IFN activity. |
| T229 |
1194-1408 |
Sentence |
denotes |
In line with the impaired IFN signaling, robust downregulation of some of the ISGs (MX1, IFITM1, IFIT2) observed in severe and critically ill patients suggest an overall reduced IFN response (Hadjadj et al., 2020). |
