| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T176 |
0-247 |
Sentence |
denotes |
In agreement with the critical role of early IFN response in attenuating infectious state, another study finds that cells pre-treated with IFN-β or IFN-λ exhibit resistance to SARS-CoV-2 infection by significantly decreasing the virus copy number. |
| T177 |
248-350 |
Sentence |
denotes |
Similarly, 3D culture organoids pre-treated with either IFN-β or IFN-λ led to reduced viral infection. |
| T178 |
351-565 |
Sentence |
denotes |
Cells depleted for either IFNAR1 or IFNLR1 had an overall increase in the number of SARS-CoV-2 infected cells, suggesting the integral role of IFN signaling in attenuating viral propagation (Stanifer et al., 2020). |
| T179 |
566-734 |
Sentence |
denotes |
Further, IFN response was adequate in younger patients compared to older ones, which may partly explain the higher risk of infection in older people (Wei et al., 2020). |
| T180 |
735-1008 |
Sentence |
denotes |
Additionally, people with comorbid conditions like diabetes – a condition associated with impaired IFN response, are more susceptible to SARS-CoV-2 infection, which further points toward the critical role of IFN signaling in the early clearance of the virus (Erener, 2020). |
| T181 |
1009-1220 |
Sentence |
denotes |
However, a comprehensive and longitudinal analysis of the IFN response in mild/moderate patients is warranted to understand the functional consequence of this immune response throughout the disease and recovery. |
| T182 |
1221-1518 |
Sentence |
denotes |
Overall, considering the relatively better IFN response and ISG expression induced by SARS-CoV-2, one can argue that this functional immune response is a probable reason for the relatively lower mortality rate seen in COVID-19, compared to previous SARS-CoV and MERS infections (Meo et al., 2020). |
| T183 |
1519-1571 |
Sentence |
denotes |
However, these early findings warrant further proof. |
