| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T159 |
0-171 |
Sentence |
denotes |
By initiating an early antiviral response, signaling via IFNs and ISGs is critical for the viral clearance and an impediment for the development of the pathological state. |
| T160 |
172-292 |
Sentence |
denotes |
Several in vitro and animal studies have established the central role of these signaling pathways in SARS-CoV infection. |
| T161 |
293-525 |
Sentence |
denotes |
STAT1 knockout mice infected with SARS-CoV exhibited severe disease symptoms, conferred by increased viral replication and propagation and was further associated with reduced survival rate (Hogan et al., 2004; Frieman et al., 2010). |
| T162 |
526-731 |
Sentence |
denotes |
Similarly, SARS-CoV propagation increases in IFNR1-/- and ILFNLR1/- double knockout mice, suggesting an essential role of these signaling pathways in mitigating antiviral response (Mahlakõiv et al., 2012). |
