| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T85 |
0-210 |
Sentence |
denotes |
The role of these molecular sensors is not yet comprehensively studied in SARS-CoV-2, but a few recent reports suggest that these sensors are similarly involved in the early antiviral response during infection. |
| T86 |
211-416 |
Sentence |
denotes |
The immunoinformatic approach revealed the presence of a wide range of ssRNA SARS-CoV-2 genome fragments as potential molecular PAMPs which were presumed to mediate signaling via endogenous TLR7/8 pathway. |
| T87 |
417-654 |
Sentence |
denotes |
Further, it is appearing that the number of PAMPs (genomic fragments) was higher in the SARS-CoV-2 genome as compared to SARS-CoV, suggesting that SARS-CoV-2 may drive relatively more robust immune response (Moreno-Eutimio et al., 2020). |
| T88 |
655-892 |
Sentence |
denotes |
Single-cell RNA-sequencing (scRNA-seq) study in PBMCs derived from ICU patients revealed extensive upregulation of NAS pathway genes including RIG-I, MDA5, and LGP2, suggesting an invasion of SARS-CoV-2 in these cells (Wei et al., 2020). |
| T89 |
893-994 |
Sentence |
denotes |
However, no direct assays were performed in these cells to find the presence or absence of viral RNA. |
| T90 |
995-1243 |
Sentence |
denotes |
These findings may imply that that the SARS-CoV-2, does not directly infect PBMCs and thus this upregulation of NAS genes may be through passive uptake of the virus, most probably by antibody-dependent enhancement (ADE), as will be discussed later. |
| T91 |
1244-1352 |
Sentence |
denotes |
Similarly, endogenous TLR7 and TLR8 upregulate along with an increase in expression of MAVS, IRF3, and IRF7. |
| T92 |
1353-1592 |
Sentence |
denotes |
The functional importance of this upregulated expression of NAS pathway genes remains unclear and hence more research in this direction will clarify the specific role of these molecular sensors in the antiviral response against SARS-CoV-2. |
