| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1007 |
0-233 |
Sentence |
denotes |
FIGURE 5 Immunopathological changes during different stages of COVID-19. (A) Immunological response in mild/moderate COVID-19 patients are overtly conferred by the adaptive immune cells with assistance from the innate immune system. |
| T1008 |
234-397 |
Sentence |
denotes |
Infected ATII cells and activated AMs produce a repertoire of cytokines and chemokines to recruit innate and adaptive immune cells and limit the viral propagation. |
| T1009 |
398-509 |
Sentence |
denotes |
The functional immune system thus acts in a well-coordinated manner to eliminate the virus specific ATII cells. |
| T1010 |
510-855 |
Sentence |
denotes |
Due to the relatively stem cell-like property of ATII cells, the eliminated cells are subsequently regenerated, thus ensuring recovery of the damaged lung tissue. (B) However, in severe/critically ill patients, an exaggerated inflammatory response is mounted by hyperactivated innate immune cells, and to a lower degree by adaptive immune cells. |
| T1011 |
856-1039 |
Sentence |
denotes |
A hyperinflammatory state is created in the lungs which is characterized by the robust accumulation of inflammatory cells like monocytes/macrophages, dendritic cells, and neutrophils. |
| T1012 |
1040-1168 |
Sentence |
denotes |
This leads to the excessive release of cytokines and chemokines by these cells, thus inducing a vicious hyperinflammatory cycle. |
| T1013 |
1169-1310 |
Sentence |
denotes |
Damage to the lung parenchyma is inflicted by this hyperinflammatory state, along with other cytotoxic molecules like MMPs, NETs, ROS and NO. |
| T1014 |
1311-1376 |
Sentence |
denotes |
The latter two combine to form more cytotoxic peroxynitrite ions. |
| T1015 |
1377-1559 |
Sentence |
denotes |
The combined action of these events results in epithelial denudation, vascular leak, platelet and RBC infiltration, vascular edema, and hyaline membrane formation, resulting in ARDS. |
