| T984 |
55-779 |
Sentence |
denotes |
6 • Single cell RNA-seq analysis was performed followed by cluster analysis to determine the immune cell type.• Proliferative and less expandable CD8+ T lymphocytes were present in severe/critically ill patient BALF samples, whereas moderate cases showed more expandable and less proliferative phenotype.• Increased macrophages and neutrophils were detected in the BALF of patients exhibiting severe/critical disease symptoms.• Higher levels of IL-1β, IL-6, and IL-8 were observed in all the patients.• Increased levels of CXCL9, CXCL10 and CXCL11 were consistently seen in all the patients.• Lung macrophages displayed higher transcripts of IL1B, IL6, TNFA, along with chemokines CCL2, CCL3, CCL4 and CCL7 in severe cases. |
