LitCovid-sentences  

PMC:7736111 / 116189-118360 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T684 0-356 Sentence denotes In addition to the mechanism mentioned above associated with lymphocytopenia, secondary signaling mediated via engagement of death receptors, increased ROS, HMGB1 and other death-inducing agents released by the infected and damaged ATII cells may also be implicated in T cell decline (Kaminskyy and Zhivotovsky, 2010; Juno et al., 2017; Zhan et al., 2017).
T685 357-568 Sentence denotes Thus, based on these early findings, lymphocyte exhaustion may be driven by multiple factors that actively engage in rendering these cells ineffective, followed by their subsequent elimination (lymphocytopenia).
T686 569-701 Sentence denotes Overall, a clear picture is emerging, which strongly indicates lymphocytopenia as a predictive marker for COVID-19 disease severity.
T687 702-921 Sentence denotes Along with increased neutrophil number, the blood lymphocyte count serves as a better prognostic marker and reflects the immunopathological state of the patients (Giamarellos-Bourboulis et al., 2020; Liu et al., 2020b).
T688 922-1051 Sentence denotes Further, based on these emerging studies, it is becoming evident that T cell response is heterogeneous during COVID-19 infection.
T689 1052-1272 Sentence denotes While peripheral blood may exhibit lymphocytopenia, and mostly exhausted status of these cells, the site of infection is associated with an activated profile of the cells and hence determines the severity of the disease.
T690 1273-1362 Sentence denotes Thus, caution should be exercised while designing therapeutic interventions for COVID-19.
T691 1363-1454 Sentence denotes The underlying immunological state should be borne in mind while considering the treatment.
T692 1455-1672 Sentence denotes Patients with lymphocytopenia and elevated functional and activation status of T cells may benefit from immunomodulatory approaches like mesenchymal stem cells, which are currently under clinical trials (NCT04377334).
T693 1673-1892 Sentence denotes Patients with imperfect T cell and B cell responses may benefit from convalescent plasma therapy, whereas patients with impaired interferon response may respond better to interferon therapies (NCT04350671; NCT04388709).
T694 1893-2059 Sentence denotes Thus, before a vaccine is available, a rational way to recommend therapy for severe cases of COVID-19 should be based on the patient’s underlying immunological state.
T695 2060-2171 Sentence denotes However, the treatment options become challenging when the patients exhibit cytokine storm and associated ARDS.