LitCovid-sentences  

PMC:7712180 / 88281-90738 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T464 0-137 Sentence denotes The ability of a virus to adapt to a human environment, including human immunity and drugs, enables it to seasonally circulate in humans.
T465 138-345 Sentence denotes Highly transmissible SARS-CoV-2, which has the same ACE2 receptor as that of HCoV-NL63, may continue to be a seasonal CoV and may undergo recombination with HCoV-NL63 during mixed infection in the same cell.
T466 346-548 Sentence denotes While there is no vaccine for and no specific drugs for treatment of mild common cold disease caused by HCoVs, many efforts are being made to develop both vaccines and drugs for the pandemic SARS-CoV-2.
T467 549-780 Sentence denotes Influenza caused by seasonal IAVs can be prevented by yearly vaccination and can be treated by FDA-approved anti-flu drugs, which are divided into four groups: M2 inhibitors, a PA inhibitor, a PB1 inhibitor and NA inhibitors [270].
T468 781-1030 Sentence denotes Nonetheless, highly mutable IAVs that possess RNA genome segments and RNA polymerase without proofreading, different from the CoV RNA genome and RNA polymerase with proofreading, have continued to circulate in humans for more than one hundred years.
T469 1031-1336 Sentence denotes Structural analysis, studies on receptor binding specificity and studies on inhibition of infection by synthetic sialylglycopolymers [19,271] have suggested that there is an invariant receptor binding site (RBS) on viral HA spikes that is critical for virus binding to a human-type receptor for infection.
T470 1337-1553 Sentence denotes This easily reachable drug target that is abundant on the viral envelope is a promising target for the development of a universal and permanent anti-influenza drug against human-adapted viruses of H1–H16 HA subtypes.
T471 1554-1755 Sentence denotes Recently, 6SLN-lipo PGA [270,271] was shown to be effective when administered alone and to have a synergistic effect when combined with an NAI drug against both pandemic and seasonal influenza viruses.
T472 1756-1818 Sentence denotes In the case of CoVs, the RBS could be a potential drug target.
T473 1819-1995 Sentence denotes However, CoVs recognize different receptors including protein receptors, CEACAM1a, NCAM, DDP4, APN and ACE2, and saccharide receptors, sialylated or non-sialylated saccharides.
T474 1996-2196 Sentence denotes Some CoVs also recognize a co-receptor/attachment factor by a different binding pocket of the S protein and some βCoVs also carry an HE spike protein binding to an O-acetylated Sia receptor (Table 2).
T475 2197-2457 Sentence denotes Thus, for the design of an anti-CoV against the RBS, consideration must be given to the role and importance of each receptor and to the use of two inhibitors in combination or the possibility of generating a single compound with two different inhibitory sites.