LitCovid-sentences  

PMC:7712180 / 80382-82273 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T424 0-183 Sentence denotes Observation of agglutination of human erythrocytes by intact MERS-CoV particles led to the finding that Sia-binding activity of MERS-CoV is mediated by multivalent S1A (S1-NTD) [112].
T425 184-352 Sentence denotes One hundred thirty-five glycan structures were used for determination of receptor binding specificity of multivalent MERS-S1A-containing nanoparticles by glycan arrays.
T426 353-479 Sentence denotes It appeared that MERS-S1A nanoparticles bind selectively to nonmodified Neu5Ac but not to Neu5Gc or (7,)9-O-acetylated Neu5Ac.
T427 480-669 Sentence denotes No binding to Neu5Gc-terminated glycans was explained by steric hindrance of the extra hydroxyl group of Neu5Gc in the MERS- S1A hydrophobic pocket formed by F39, F101, I131 and I132 [148].
T428 670-867 Sentence denotes For sialyl linkage specificity, MERS-CoV S1A prefers α2,3 over α2,6 linkages, either short, sulfated, α2,3-linked mono-Sia LewisX or long, branched, α2,3-linked tri-Sia with four type 2 LN repeats.
T429 868-1018 Sentence denotes Pretreatment of Calu-3 human airway cells with neuraminidase inhibited infection of MERS-CoV, indicating that Sia is necessary for MERS-CoV infection.
T430 1019-1388 Sentence denotes Accordingly, multivalent MERS-CoV S1A-containing nanoparticles were shown to specifically bind to infection sites in individual hosts: dromedary camel nasal epithelial cells, human type II pneumocytes in the alveolar wall that contains an abundance of α2,3-sialyl type 2 LN and a small amount of α2,3-sialyl-LewisX [19], and pipistrelle bat intestinal epithelial cells.
T431 1389-1581 Sentence denotes Removal of Sia from cell surface glycans by treatment with neuraminidase abolished binding of the nanoparticles, confirming that MERS-CoV S1A binds to infected cells via Sia recognition [108].
T432 1582-1648 Sentence denotes The cryo-EM structure of MERS-CoV S in complex with α2,3-SLN (pdb:
T433 1649-1746 Sentence denotes 6q06) showed Sia binding in a surface-exposed groove (domain A) of each monomer (Figure 9, left).
T434 1747-1891 Sentence denotes Analysis of the structure indicated the five residues Q36, A92, I132, S133 and R307 directly anchoring Neu5Ac as shown in Figure 9, right [148].