LitCovid-sentences  

PMC:7712180 / 29989-33655 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T176 0-4 Sentence denotes 3.5.
T177 5-62 Sentence denotes Influenza D Viruses Use Neu5,9Ac2 and Neu5Gc9Ac Receptors
T178 63-401 Sentence denotes In 2011, a novel virus isolated from a nasal swab of a 15-week-old pig with influenza-like symptoms in Oklahoma in the USA was found to possess seven (-)ssRNA genomic segments and HEF spike glycoproteins and to share approximately 50% overall aa sequence identity with human ICVs, and it was named C/swine/Oklahoma/1334/2011 (C/OK) [183].
T179 402-667 Sentence denotes At first, it was suggested to be a new subtype of ICVs due to (i) no cross-reaction of C/OK with human ICVs determined by hemagglutination inhibition assays and (ii) a wider cellular tropism of C/OK than that of a human ICV determined by cell culture studies [183].
T180 668-946 Sentence denotes In 2016, however, it was determined by the International Committee on Taxonomy of Viruses that this novel influenza virus is distinct from other types, and it was officially classified in a new genus, Deltainfluenzavirus, and so-called influenza D virus (IDV, type (species) D).
T181 947-1420 Sentence denotes As shown in Table 1, in addition to pigs, IDVs have been isolated from cattle and have so far been classified into three lineages: D/OK (D/swine/Oklahoma/1334/2011-like viruses), D/660 (D/bovine/Oklahoma/660/2013-like viruses) and D/Japanese, with D/Japanese lineage being further classified into 2 sublineages, D/Yama2016 (D/bovine/Yamagata/10710/2016-like viruses) and D/Yama2019 (D/bovine/Yamagata/1/2019-like viruses), based on phylogenetic and antigenic analyses [73].
T182 1421-1617 Sentence denotes Although there has been only serological evidence suggesting that IDV can infect humans [15], the virus may acquire mutations to potentially infect humans and to cause influenza illness in humans.
T183 1618-1711 Sentence denotes The host range of IVs is primarily determined by receptor binding specificity of the viruses.
T184 1712-1846 Sentence denotes Recently, Liu et al. compared receptor binding specificities of IDVs and their related ICVs by a sialoglycan microarray approach [72].
T185 1847-2177 Sentence denotes Strain D/swine/Oklahoma/1334/2011 (D/OK) showed preferential binding to Neu5,9Ac2 and Neu5Gc9Ac either linked to α2,6Gal or α2,3Gal and strain D/bovine/Oklahoma/660/2013 /660) preferred to bind to Neu5,9Ac2α2,6Gal, Neu5Gc9Acα2,6Gal and Neu5Gc9Acα2,3Gal, whereas strain C/Johannesburg/1/1966 dominantly recognized Neu5,9Ac2α2,6Gal.
T186 2178-2313 Sentence denotes The broader receptor recognition by IDVs than by human ICV could explain why cellular tropism of IDVs is wider than that of human ICVs.
T187 2314-2469 Sentence denotes Binding of IDVs to both Neu5,9Ac2 and Neu5Gc9Ac, different from human ICV binding to Neu5,9Ac2, could be determined by their different HEF-binding pockets.
T188 2470-2847 Sentence denotes It was shown that different from human ICV HEF of C/Johannesburg/1/1966, swine IDV HEF of D/OK has an open cavity between the 230-helix and 270-loop in the receptor-binding site, which is thought to allow for accommodation of diverse glycan receptors, including Neu5Gc9Ac harboring an extra hydroxyl group on the N-acetyl group of C5 Neu5Gc and different sialyl linkages [184].
T189 2848-3022 Sentence denotes Further investigation of the structure of the bovine IDV HEF-binding pocket might lead to an understanding of different receptor binding preferences of swine and bovine IDVs.
T190 3023-3136 Sentence denotes Receptor binding specificity of viruses is believed to be associated with receptors present on the target tissue.
T191 3137-3329 Sentence denotes Glycoconjugate structures terminated with Neu5,9Ac2 and Neu5Gc9Ac along the bovine, porcine and human respiratory tracts have not been determined and further investigation is therefore needed.
T192 3330-3666 Sentence denotes Previous findings that there is no Neu5Gc production in healthy humans due to mutation of a gene encoding CMP-Neu5Ac hydroxylase, which converts CMP-Neu5Ac to CMP-Neu5Gc [42,185], could explain why human ICVs prefer binding to Neu5,9Ac2, whereas swine and bovine IDVs can bind preferentially to both Neu5,9Ac2 and 9-O-acetylated Neu5Gc.