LitCovid-sentences  

PMC:7696151 / 9884-12328 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T83 0-129 Sentence denotes The first randomized, double-blind, placebo-controlled clinical trial about the anti-HIV-1 activity of HCQ was published in 1995.
T84 130-241 Sentence denotes In this study, 40 asymptomatic HIV-infected patients received either 800 mg/day HCQ or placebo for eight weeks.
T85 242-431 Sentence denotes All patients treated with antiretroviral therapy (HAART = zidovudine (ZDV), 2′,3′-dideoxyinosine, or 2′,3′-dideoxycytidine) and stopped taking it four weeks before the clinical trial start.
T86 432-552 Sentence denotes Unlike placebo, at the eighth week, HCQ displayed a reduction in HIV-1 RNA total plasma levels in 12 out of 19 patients.
T87 553-765 Sentence denotes Furthermore, the percentage of CD4+ T cells decreased significantly in the placebo group and remained stable during the treatment with HCQ, indicating a probable stabilization of immune function in the HCQ group.
T88 766-866 Sentence denotes HCQ administration also induced a decrease in serum interleukin 6 (IL-6) and immunoglobulin G (IgG).
T89 867-941 Sentence denotes However, no significant changes were found in the IgA and IgM levels [17].
T90 942-1157 Sentence denotes The anti-HIV-1 effect of HCQ was also compared with that of ZDV, a nucleoside reverse transcriptase inhibitor, in a randomized, placebo-controlled clinical trial conducted on 72 HIV-l-infected asymptomatic patients.
T91 1158-1253 Sentence denotes All subjects were treated for 16 weeks with 800 mg/day HCQ (n = 35) or 500 mg/day ZDV (n = 37).
T92 1254-1376 Sentence denotes As in the previous study, patients who had received HAART stopped taking it four weeks before the clinical trial’s outset.
T93 1377-1577 Sentence denotes After 16 weeks, total plasma HIV-1 RNA levels were reduced in both the ZDV group and HCQ group, although the extent of anti-HIV-l activity in HCQ patients was lower than that observed in ZDV subjects.
T94 1578-1742 Sentence denotes However, eight subjects in the Azithromycin (AZM) group showed an increase in HIV-1 RNA levels in the 16th week, indicating the rapid emergence of viral resistance.
T95 1743-1948 Sentence denotes Contrarily, in the HCQ group, increased antiviral activity was revealed after 16 weeks rather than after 8 weeks, and no subject showed an increase in HIV-1 RNA levels at either 8 or 16 weeks of treatment.
T96 1949-2071 Sentence denotes This evidence suggests that no resistance developed under HCQ therapy or that it might develop more slowly than under ZDV.
T97 2072-2244 Sentence denotes A reduction in serum p24 antigen levels in both ZDV and HCQ groups was also described, while only in the HCQ group could a decrease in IL-6 and IgG levels be observed [18].
T98 2245-2444 Sentence denotes This reduction of IgG levels displayed after HCQ treatment in both studies may be significant since autoantibodies contribute to CD4+ cell depletion and autoimmune diseases observed in HIV infection.