| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T74 |
0-115 |
Sentence |
denotes |
HIV is part of the genus Lentivirus, of the Retroviridae family, and it is divided into two lines: HIV-1 and HIV-2. |
| T75 |
116-215 |
Sentence |
denotes |
The most virulent and infectious is HIV-1, since it causes most of the HIV infections in the world. |
| T76 |
216-355 |
Sentence |
denotes |
The target cells of HIV are those rich in CD4 receptors, such as some lymphocytes called CD4+, which play a crucial role in human immunity. |
| T77 |
356-486 |
Sentence |
denotes |
Indeed, these lymphocytes activate different immune system cells depending on the type of unwanted host they come in contact with. |
| T78 |
487-598 |
Sentence |
denotes |
It seems that acute HIV infection is highly linked to a rapid depletion of CD4+ T cells in gut lymphoid tissue. |
| T79 |
599-771 |
Sentence |
denotes |
This event is related to an alteration of the intestinal mucosa integrity, resulting in bloodstream translocation of microbial products like lipopolysaccharides (LPS) [42]. |
| T80 |
772-949 |
Sentence |
denotes |
It has been hypothesized that LPS, through the binding and activation of Toll-like receptor 4 (TLR-4), is responsible for the immune system activation observed in HIV infection. |
| T81 |
950-1164 |
Sentence |
denotes |
Although the real HCQ mechanism of action has not been well assessed, it seems that the anti-HIV effects are highly linked to the post-translational modification of glycoprotein 120 (gp120) in monocyte and T cells. |
| T82 |
1165-1287 |
Sentence |
denotes |
Consequently, there was a modification of gp120 immunogenic properties and a reduction of new virions infectivity [15,16]. |
