LitCovid-sentences  

PMC:7696151 / 75834-77846 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T486 0-155 Sentence denotes In other cancer types, such as ovarian, prostatic, and human breast cancer, the anticancer or pro-tumorigenic effects of HCQ are determined by tumor stage.
T487 156-326 Sentence denotes In the early stages of the disease, the inhibition of autophagy results in an inhibition of tumorigenesis, while in the advanced phase, it enhances cancer survival [145].
T488 327-421 Sentence denotes Then, it is important in assessing the contextual role of HCQ in cancer resistance mechanisms.
T489 422-528 Sentence denotes Epirubicin in triple-negative breast cancer therapy often lost efficacy, due to chemoresistance acquiring.
T490 529-630 Sentence denotes It has been shown that this cytotoxic agent induced autophagic flux, increasing cancer cell survival.
T491 631-808 Sentence denotes The combination with HCQ (120 mg/kg by i.p.), thanks to the anti-autophagic properties, significantly suppressed tumor growth by up to 50% with respect to the monotherapy [142].
T492 809-950 Sentence denotes In addition, estrogen receptor-positive breast cancers developed resistance to treatment with tamoxifen, due to the enhancement of autophagy.
T493 951-1078 Sentence denotes The coadministration of HCQ (1–2 mg/day/mice in drinking water) restored the susceptibility of cancer cells to tamoxifen [146].
T494 1079-1347 Sentence denotes In mice with thyroid gland xenograft carcinoma, HCQ (150 mg/kg/day p.o. for two weeks) did not provide significant results on tumor growth, while the combination of HCQ with the chemotherapic agent vemurafenib potentiated the anticancer properties of both drugs [147].
T495 1348-1595 Sentence denotes Similarly, the two weeks coadministration of HCQ (65 mg/kg) and CCI-779 resulted in a synergism that significantly enhanced their in vivo activity against melanoma tumor growth, in terms of tumor size, with respect to their single treatment [148].
T496 1596-1666 Sentence denotes HCQ was revealed also to be active against chemoresistant lung cancer.
T497 1667-1838 Sentence denotes In this type of cancer, the hypoxic conditions led to lesser susceptibility of cancer cells towards lymphocyte T-mediated cytolysis, thanks to the activation of autophagy.
T498 1839-2012 Sentence denotes HCQ intake, at doses of 30 mg/kg/day i.p. for 10 days, sensitized tumor cells to lysis and allowed, together with conventional treatment, the eradication of the tumor [149].