| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T452 |
0-6 |
Sentence |
denotes |
2.4.2. |
| T453 |
7-37 |
Sentence |
denotes |
Cardiovascular Risk Management |
| T454 |
38-167 |
Sentence |
denotes |
HCQ revealed the great potential in the management of cardiovascular risk by controlling glucose homeostasis and lipidic profile. |
| T455 |
168-306 |
Sentence |
denotes |
Until now, in this review, we discussed the effect of HCQ alone to counteract cardiovascular complications, mostly in autoimmune patients. |
| T456 |
307-452 |
Sentence |
denotes |
Here, we reviewed the multiple pleiotropic actions of HCQ in combination with conventional medication in the most common cardiovascular diseases. |
| T457 |
453-672 |
Sentence |
denotes |
The cardioprotective effects of one week of treatment with 50 mg/kg of HCQ i.g. against ischemia-reperfusion injury in type-2 diabetic mice were assessed in combination with the phosphodiesterase-5 inhibitor, tadalafil. |
| T458 |
673-798 |
Sentence |
denotes |
The synergistic effect reduced the myocardial infarct size by up to 20% and improved insulin secretion and sensitivity [132]. |
| T459 |
799-1011 |
Sentence |
denotes |
Moreover, low-dose HCQ (3.4 mg/kg/day) prevented cardiomyocyte apoptosis in the periinfarct myocardium, dampening ischemic cardiomyopathy, and cardiac stroke, as demonstrated by Jalal, et al. [133] in rat models. |
| T460 |
1012-1148 |
Sentence |
denotes |
The role of HCQ in the inhibition of platelet aggregation was evaluated in healthy volunteers in comparison with aspirin or clopidogrel. |
| T461 |
1149-1261 |
Sentence |
denotes |
The addition of 400 mg/day of HCQ to aspirin resulted in a significant increase in aggregation inhibition (31%). |
| T462 |
1262-1391 |
Sentence |
denotes |
This inhibition was passed by reducing fibrinogen and inflammatory status by interfering with the arachidonic acid cascade [134]. |
