| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T444 |
0-114 |
Sentence |
denotes |
In addition to rheumatoid arthritis patients, HCQ is also used in lupus erythematosus, another autoimmune disease. |
| T445 |
115-165 |
Sentence |
denotes |
Regarding lupus erythematosus, HCQ is widely used. |
| T446 |
166-505 |
Sentence |
denotes |
In vivo studies on a NZB/W F1 murine model of lupus showed that HCQ in combination with PRD (2.5 mg/kg/day and 1 mg/kg/day p.o.) decreased autoantibody production, as well as being able to inhibit toll-like receptor activation, resulting in the down-regulation of type I interferon (IFN-α) which is deeply implicated in lupus pathogenesis. |
| T447 |
506-814 |
Sentence |
denotes |
The efficacy of treatment is due to the ability of drugs to alter the expression of urinary and immune cell micro RNA that contribute to lupus progression by post-transcriptional modulation of genes involved in the immune response, pro-inflammatory cytokines production and toll-like receptor pathways [129]. |
| T448 |
815-921 |
Sentence |
denotes |
In association with low-dose aspirin, HCQ is also indicated for thromboprophylaxis in patients with lupus. |
| T449 |
922-1216 |
Sentence |
denotes |
The occurrence of thrombotic events was recorded for 13 years in 189 patients, showing that the cardiovascular complications were more frequent in patients treated only with aspirin, while HCQ (up to 600 mg) was associated with a stronger thrombo-protective effect in patients with lupus [130]. |
