LitCovid-sentences  

PMC:7696151 / 57113-59236 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T366 0-6 Sentence denotes 2.3.4.
T367 7-23 Sentence denotes Sjögren Syndrome
T368 24-138 Sentence denotes Sjögren syndrome is an autoimmune disease with a strong negative impact on the quality of life of affected people.
T369 139-268 Sentence denotes The main features of the disease are lymphocytic inflammation and alterations in major salivary glands, causing xerostomia [103].
T370 269-423 Sentence denotes Even if preliminary results about HCQ use in Sjögren syndrome were not encouraging, to date it arises as one of the first-line drugs in disease treatment.
T371 424-714 Sentence denotes Indeed, an earlier prospective, a two-year double-blind crossover trial on 19 subjects correlated an annual intake of a dose of 400 mg/day with no significant improvements in clinical symptoms and signs of pathology, including tear and salivary gland activity, respect to the placebo [121].
T372 715-826 Sentence denotes However, a few years later, the first evidence of HCQ effectiveness in Sjögren syndrome treatment was reported.
T373 827-1060 Sentence denotes Annual treatment with a dose of 200 mg/day of HCQ showed anti-lymphoproliferative and anti-inflammatory effects, with a reduction of IgG and IgA immunoglobulins, anti-Sjögren autoantibodies, and erythrocyte sedimentation rates [100].
T374 1061-1321 Sentence denotes Moreover, the salivary flow rate increased in Sjögren syndrome women who received a daily dose of 400 mg of HCQ for 30 weeks [101], while eye dryness was alleviated by HCQ administration (6.5 mg/kg), as demonstrated by a prospective study on 32 patients [102].
T375 1322-1480 Sentence denotes Hypo-salivation deriving from acinar atrophy and fibrosis of salivary glands is often associated with over-expression of TGF-β (transforming growth factor-β).
T376 1481-1703 Sentence denotes Treatment with HCQ downregulated TGF-β levels in a randomized trial on NOD mice exposed to doses of 50 mg/kg/day intragastrically (i.g.) for 16 weeks, with significant results in delaying loss of saliva secretory function.
T377 1704-1830 Sentence denotes Moreover, HCQ intake was also accompanied by a decrease in autoantibody production and a lower lymphocytic infiltration [103].
T378 1831-2123 Sentence denotes These findings were confirmed by Wu, Pu, Yu and Li [104], showing that 8-weeks treatment with HCQ administered at a dose of 60 mg/kg i.g. in 40 randomized NOD mice led to lower lymphocytic infiltration, with a significant improvement in pathological changes in submandibular gland morphology.