PMC:7696151 / 34350-37404 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T228 0-145 Sentence denotes Despite the lack of real antiviral evidence related to HCQ administration, this drug has also been investigated as a possible prophylactic agent.
T229 146-349 Sentence denotes In fact, the pharmacokinetics of HCQ, like its long half-life and the high concentration in the lung (500-times higher than blood concentration), has made it an ideal candidate for prophylactic use [56].
T230 350-495 Sentence denotes The first study conducted on this line was performed in South Korea on 211 virus-exposed individuals, including 189 patients and 22 care-workers.
T231 496-728 Sentence denotes The HCQ administration (400 mg day) as post-exposure prophylaxis resulted in the negative follow-up PCR tests after the end of 14 days of quarantine period (only 97.4% of patients and 95.5% of care-workers completed the study) [40].
T232 729-897 Sentence denotes However, it is necessary to consider that this is a single-center clinical study with a high risk of bias and that a subsequent randomized clinical study has denied it.
T233 898-1062 Sentence denotes In particular, Boulware D.R. et al., in a randomized, double-blind, placebo-controlled trial, tested HCQ as a prophylactic agent within 4 days after virus exposure.
T234 1063-1244 Sentence denotes There were 821 asymptomatic participants randomly assigned to receive either placebo or HCQ (800 mg once, followed by 600 mg in 6 to 8 h, then 600 mg per day for 4 additional days).
T235 1245-1540 Sentence denotes After 14 days of treatment, it was demonstrated that HCQ did not prevent COVID-19 infection when compared to placebo, since the incidence of illnesses compatible with Covid-19 disease did not differ significantly between subjects receiving HCQ (49 of 414 (11.8%)) or placebo (58 of 407 (14.3%)).
T236 1541-1663 Sentence denotes Furthermore, the onset of side effects was more frequent in patients treated with HCQ than placebo (40.1% vs. 16.8%) [41].
T237 1664-1826 Sentence denotes To better assess the incidence of side effects linked to HCQ administration as post-exposure prophylaxis, a cross-sectional study was conducted among 140 doctors.
T238 1827-2075 Sentence denotes Sixty nine adverse events were documented in 44 subjects (31%); the most common reported symptoms were headache followed by nausea, dizziness, abdominal cramps, and loose stools, while hypoglycemia was seen in only three diabetic participants [57].
T239 2076-2227 Sentence denotes Hence, even if the side effects highlighted were not serious, it is recommended to take the utmost care before using HCQ for COVID-19 chemoprophylaxis.
T240 2228-2358 Sentence denotes The ineffectiveness of HCQ administration as post-exposure prophylaxis has also been demonstrated by an in vivo study on macaques.
T241 2359-2493 Sentence denotes Maisonnasse P. et al. tested different treatment strategies, including HCQ alone or in combination with AZM, in comparison to placebo.
T242 2494-2559 Sentence denotes All the treatments were administrated before or after viral load.
T243 2560-2693 Sentence denotes It was seen that when HCQ was administrated as pre-exposure prophylaxis, it did not protect against the acquisition of the infection.
T244 2694-2866 Sentence denotes Similarly, neither HCQ nor HCQ + AZM had beneficial effects in improving viral infection’s symptoms [58], confirming previously analyzed clinical studies’ negative results.
T245 2867-3054 Sentence denotes Several case reports have supported all these results since people already using HCQ for a long time to treat inflammatory diseases also showed severe illness related to COVID-19 [59,60].