LitCovid-sentences  

PMC:7696151 / 23011-25693 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T160 0-6 Sentence denotes 2.2.3.
T161 7-19 Sentence denotes Flaviviruses
T162 20-257 Sentence denotes Hepatitis virus, an RNA virus belonging to the Flaviviridae family, is closely related to liver disease, which in 70–80% of patients becomes chronic, resulting in major complications such as cirrhosis and, in the year, also liver cancer.
T163 258-354 Sentence denotes The antiviral activity of HCQ on the hepatitis C virus (HCV) in monotherapy has not been tested.
T164 355-437 Sentence denotes However, it seems that this drug increases the antiviral effect of standard drugs.
T165 438-680 Sentence denotes In a study including 120 Egyptian patients infected by the hepatitis C virus, it was seen that the combination of HCQ with pegylated interferon and ribavirin could improve biochemical and virological responses in chronic hepatitis C subjects.
T166 681-938 Sentence denotes All patients were randomized and divided into two groups; the control group treated with standard-of-care (SOC) consisted of 160 µg of subcutaneous pegylated interferon and 1000–12000 mg/day of oral ribavirin, and the group treated with 200 mg HCQ plus SOC.
T167 939-1115 Sentence denotes At the end of the treatment (12 weeks), patients of HCQ + SOC group showed a high virological response compared to the control group (54/60 (90%) vs. 43/60 (71.7%); p = 0.011).
T168 1116-1334 Sentence denotes Moreover, in the HCQ + SOC group, there was a normalization of ALT levels, as is also demonstrated by the earlier biochemical response (EBR) highlighted in HCQ + SOC group 58/60 (96.7%) than SOC group 42/60 (70%) [30].
T169 1335-1461 Sentence denotes These results were confirmed by several case reports regarding patient treatment with Porphyria Cutanea Tarda and Hepatitis C.
T170 1462-1654 Sentence denotes It was seen that a low dose of HCQ (100 mg twice weekly) prevented the recurrence of Porphyria Tarda and reduced the viral response during HCV therapy, including ribavirin and interferon [45].
T171 1655-1912 Sentence denotes Furthermore, in a patient with chronic hepatitis and rheumatoid arthritis, a low risk for hepatitis virus reactivation was observed after treatment with steroids (< 7.5 mg/day), HCQ or sulfadiazine [46] in combination with antivirals as prophylaxis [47,48].
T172 1913-2081 Sentence denotes Another possible antiviral effect of HCQ is exerted on Zika virus (ZIKV), an RNA virus of the Flaviviridae family transmitted by numerous mosquitoes of the genus Aedes.
T173 2082-2269 Sentence denotes No clinical studies have been conducted yet, but an in vivo study has demonstrated the ability of HCQ to attenuate vertical transmission of ZIKV by reducing placental and fetal infection.
T174 2270-2403 Sentence denotes In this study, pregnant mice were treated with 40 mg/kg/day HCQ via intraperitoneal injection beginning one day after ZIKV infection.
T175 2404-2570 Sentence denotes It was seen that HCQ acted as an autophagy inhibitor by increasing p62 levels in trophoblast and thus reducing placental ZIKV infection and fetal growth defects [31].
T176 2571-2682 Sentence denotes To date, no clinical trials have been conducted to evaluate HCQ antiviral effects in patients infected by ZIKV.