LitCovid-sentences  

PMC:7696151 / 13057-15709 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T103 0-135 Sentence denotes Since monotherapy is not recommended in treating HIV, HCQ has also been tested in synergy with other drugs commonly used to manage HIV.
T104 136-385 Sentence denotes In this regard, 400 mg/day of HCQ in a combination regimen with 1000 mg/day hydroxyurea and 250–400 mg/day didanosine (dosed per body weight) was administered for 48 weeks to 22 asymptomatic HIV-1 infected patients naïve to antiretroviral treatment.
T105 386-428 Sentence denotes Only 16 out of 22 patients were evaluable.
T106 429-552 Sentence denotes These 16 subjects, at the 12th week, showed a significant reduction in viral load which was maintained until the 48th week.
T107 553-680 Sentence denotes Furthermore, at week 12, an increase in CD4+ percentage was also shown, and this improvement was kept until the 48th week [19].
T108 681-846 Sentence denotes To evaluate the long-term efficacy and safety of HCQ, hydroxyurea, and didanosine combination, they were also tested on 17 HIV-infected naïve patients for 144 weeks.
T109 847-939 Sentence denotes All subjects received 200 mg HCQ, 500 mg hydroxyurea, and 125–200 mg didanosine twice daily.
T110 940-1026 Sentence denotes Of the 17 patients who started treatment, 14 remained until the end of the 144th week.
T111 1027-1284 Sentence denotes After 114 weeks, viral load was reduced by 1.6 Log10 copies/mL under baseline (p < 0.001), eight patients (47%) had an unnoticeable viral load (< 400 copies/mL), and two patients (12%) had a measurable viral load, but resistance mutations were not detected.
T112 1285-1525 Sentence denotes Four patients (24%) had both detectable viral load and resistance mutation: one with both 62V and 65R and three with both 74V and 184V mutations; the latter three were assessed as didanosine resistant, while no resistance was found for HCQ.
T113 1526-1610 Sentence denotes However, in all cases, the viral load remained below the baseline at the 144th week.
T114 1611-1732 Sentence denotes The CD4+ cell count had increased significantly, while the percentage of CD8 cells was reduced up to the 144th week [20].
T115 1733-1965 Sentence denotes This HCQ noticeable impact on immune activation, thereby increasing CD4+ T cells, was also demonstrated in a prospective study conducted on 20 HIV-infected immunologic no responders treated with standard antiretroviral therapy [23].
T116 1966-2130 Sentence denotes These results suggested that the combination of HCQ, hydroxyurea, and didanosine could be a valid alternative to the highly active commercial HAART in HIV-patients.
T117 2131-2269 Sentence denotes Nonetheless, these latter studies have some limitations, such as the small number of subjects included and the absence of a control group.
T118 2270-2419 Sentence denotes Therefore, it is not possible to determine the contribution made by HCQ to the overall decrease in viral load obtained from the combination of drugs.
T119 2420-2652 Sentence denotes Anyway, the potential anti-HIV efficacy of HCQ, when added to existing treatment with an antiretroviral regimen, was also confirmed by a case report about a patient with HLA-B27-associated spondyloarthropathy and HIV infection [43].