Id |
Subject |
Object |
Predicate |
Lexical cue |
T794 |
0-69 |
Sentence |
denotes |
Disease Experimental Model Dosage Mechanisms of Action References |
T795 |
70-172 |
Sentence |
denotes |
Rheumatoid arthritis (RA) Preclinical 40 mg/kg/day ↓neutrophil-derived oxidants ↓inflammation [75] |
T796 |
173-267 |
Sentence |
denotes |
Clinical (randomized double-blind, placebo-controlled trial) 7 mg/kg/day ↓inflammation [76] |
T797 |
268-360 |
Sentence |
denotes |
Clinical (comparative randomized double-blind trial) 200–400 mg/day ↓inflammation [77,78] |
T798 |
361-450 |
Sentence |
denotes |
RA-associated cardiovascular disease Clinical n.a. ↓IL-6 and leptin↓dyslipidemia [79] |
T799 |
451-532 |
Sentence |
denotes |
Clinical (cohort study) 6.5 mg/kg/day ↓triglycerides and LDL↓dyslipidemia [80] |
T800 |
533-640 |
Sentence |
denotes |
Clinical (randomized double-blind cross-over trial) 6.5 mg/kg/day ↓cholesterol and LDL↓dyslipidemia [81] |
T801 |
641-726 |
Sentence |
denotes |
Clinical (cross-sectional observational study) 200 mg/kg/day ↓fasting glucose [82] |
T802 |
727-884 |
Sentence |
denotes |
Systemic lupus erythematosus (SLE) Clinical (randomized double-blind placebo-controlled trial) 100–400 mg/kg/day ↓inflammation↓risk of exacerbations [83] |
T803 |
885-977 |
Sentence |
denotes |
Clinical (long-term randomized study) 272 mg/day ↓inflammation↓risk of exacerbations [84] |
T804 |
978-1053 |
Sentence |
denotes |
Clinical (case-control study) 6.5 mg/kg/day ↓inflammation↑ survival [85] |
T805 |
1054-1134 |
Sentence |
denotes |
Preclinical 100 mg/kg/day ↓Th17 response ↑Treg immunosuppressive effects [86] |
T806 |
1135-1211 |
Sentence |
denotes |
Clinical (prospective cohort study) 400 mg/day ↓inflammatory markers [87] |
T807 |
1212-1264 |
Sentence |
denotes |
Clinical (multiethnic US cohort) n.a. ↓IFN-α [88] |
T808 |
1265-1325 |
Sentence |
denotes |
Preclinical 4–40 mg/kg/day ↓ mast cells↓ skin lesion [89] |
T809 |
1326-1421 |
Sentence |
denotes |
SLE-associated cardiovascular disease Preclinical 10 mg/kg/day ↓ROS↓endothelial damage [90] |
T810 |
1422-1495 |
Sentence |
denotes |
Preclinical 3 mg/kg/day ↓ROS and nitric oxide↓ endothelial damage [91] |
T811 |
1496-1546 |
Sentence |
denotes |
Clinical 400 mg/day ↓triglycerides and LDL [92] |
T812 |
1547-1616 |
Sentence |
denotes |
Clinical (cross-sectional study) 400 mg/day ↓ fasting glucose [82] |
T813 |
1617-1718 |
Sentence |
denotes |
SLE-associated pregnancy complications Clinical (randomized double-blind) n.a. ↓inflammation [93] |
T814 |
1719-1805 |
Sentence |
denotes |
Clinical (prospective study) 6.5 mg/kg/day ↓inflammation↓risk of exacerbations [94] |
T815 |
1806-1923 |
Sentence |
denotes |
Antiphospholipid syndrome Preclinical 200 μg/day ↓inflammation↓complement activation↓placental abnormalities [95] |
T816 |
1924-1986 |
Sentence |
denotes |
Clinical (case report) 400 mg/day ↓vascular thrombosis [96] |
T817 |
1987-2061 |
Sentence |
denotes |
Preclinical 12 μg/g/day ↓endothelial damage ↓nitric oxide synthase [97] |
T818 |
2062-2137 |
Sentence |
denotes |
Preclinical 20 mg/kg/day ↓endothelial damage ↓nitric oxide synthase [98] |
T819 |
2138-2261 |
Sentence |
denotes |
Clinical (observational prospective study) 200 mg/day ↓thrombotic events in patients ↓soluble tissue factor levels. [99] |
T820 |
2262-2335 |
Sentence |
denotes |
Sjögren syndrome Clinical 200 mg/day ↓inflammation ↓IgG and IgA [100] |
T821 |
2336-2396 |
Sentence |
denotes |
Clinical (prospective study) 400 mg/day ↓xerostomia [101] |
T822 |
2397-2457 |
Sentence |
denotes |
Clinical (prospective study) 6.5 mg/kg ↓eye dryness [102] |
T823 |
2458-2525 |
Sentence |
denotes |
Preclinical 50 mg/kg/day ↓ xerostomia ↓ TGF-β↓inflammation [103] |
T824 |
2526-2598 |
Sentence |
denotes |
Preclinical 60 mg/kg/day ↓inflammation↓lymphocytic infiltration [104] |
T825 |
2599-2665 |
Sentence |
denotes |
Diabetes Preclinical 80–120–160 mg/kg/day ↓blood glucose [105] |
T826 |
2666-2740 |
Sentence |
denotes |
Preclinical 200 mg/kg/day ↓inflammatory markers↑metabolic profile [106] |
T827 |
2741-2828 |
Sentence |
denotes |
Clinical (randomized, double-blinded study) 2 × 300 mg/kg ↓glycated hemoglobin [107] |
T828 |
2829-2912 |
Sentence |
denotes |
Clinical (open-label longitudinal study) 6.5 mg/kg/day ↓insulin resistance [108] |
T829 |
2913-3010 |
Sentence |
denotes |
Clinical (randomized, double-blinded controlled trial) 6.5 mg/kg/day ↓insulin resistance [109] |
T830 |
3011-3104 |
Sentence |
denotes |
Clinical (randomized, double-blinded trial) 400 mg/day ↑glycemic and lipidic profile [110] |
T831 |
3105-3201 |
Sentence |
denotes |
Cancer Preclinical 50 mg/kg ↓tumor size↓pro-tumorigenic and pro-inflammatory cytokines [111] |
T832 |
3202-3286 |
Sentence |
denotes |
Cardiovascular diseases Preclinical 200 mg/kg ↓apoptosis in cardiomyocites [112] |
T833 |
3287-3344 |
Sentence |
denotes |
Preclinical 200 mg/kg/day ↓triglycerides and LDL [113] |
T834 |
3345-3408 |
Sentence |
denotes |
Preclinical 10 mg/kg/day ↓atherosclerosis↓inflammation [114] |
T835 |
3409-3491 |
Sentence |
denotes |
Inflammatory bowel disease and colitis Preclinical 30 mg/kg ↓inflammation [74] |
T836 |
3492-3563 |
Sentence |
denotes |
Pulmonary hypertension Preclinical 50 mg/kg/day ↓inflammation [115] |
T837 |
3564-3636 |
Sentence |
denotes |
Endometriosis Preclinical 60 mg/kg ↓inflammation↓lesion number [116] |