PMC:7696151 / 119790-123426 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T794 0-69 Sentence denotes Disease Experimental Model Dosage Mechanisms of Action References
T795 70-172 Sentence denotes Rheumatoid arthritis (RA) Preclinical 40 mg/kg/day ↓neutrophil-derived oxidants ↓inflammation [75]
T796 173-267 Sentence denotes Clinical (randomized double-blind, placebo-controlled trial) 7 mg/kg/day ↓inflammation [76]
T797 268-360 Sentence denotes Clinical (comparative randomized double-blind trial) 200–400 mg/day ↓inflammation [77,78]
T798 361-450 Sentence denotes RA-associated cardiovascular disease Clinical n.a. ↓IL-6 and leptin↓dyslipidemia [79]
T799 451-532 Sentence denotes Clinical (cohort study) 6.5 mg/kg/day ↓triglycerides and LDL↓dyslipidemia [80]
T800 533-640 Sentence denotes Clinical (randomized double-blind cross-over trial) 6.5 mg/kg/day ↓cholesterol and LDL↓dyslipidemia [81]
T801 641-726 Sentence denotes Clinical (cross-sectional observational study) 200 mg/kg/day ↓fasting glucose [82]
T802 727-884 Sentence denotes Systemic lupus erythematosus (SLE) Clinical (randomized double-blind placebo-controlled trial) 100–400 mg/kg/day ↓inflammation↓risk of exacerbations [83]
T803 885-977 Sentence denotes Clinical (long-term randomized study) 272 mg/day ↓inflammation↓risk of exacerbations [84]
T804 978-1053 Sentence denotes Clinical (case-control study) 6.5 mg/kg/day ↓inflammation↑ survival [85]
T805 1054-1134 Sentence denotes Preclinical 100 mg/kg/day ↓Th17 response ↑Treg immunosuppressive effects [86]
T806 1135-1211 Sentence denotes Clinical (prospective cohort study) 400 mg/day ↓inflammatory markers [87]
T807 1212-1264 Sentence denotes Clinical (multiethnic US cohort) n.a. ↓IFN-α [88]
T808 1265-1325 Sentence denotes Preclinical 4–40 mg/kg/day ↓ mast cells↓ skin lesion [89]
T809 1326-1421 Sentence denotes SLE-associated cardiovascular disease Preclinical 10 mg/kg/day ↓ROS↓endothelial damage [90]
T810 1422-1495 Sentence denotes Preclinical 3 mg/kg/day ↓ROS and nitric oxide↓ endothelial damage [91]
T811 1496-1546 Sentence denotes Clinical 400 mg/day ↓triglycerides and LDL [92]
T812 1547-1616 Sentence denotes Clinical (cross-sectional study) 400 mg/day ↓ fasting glucose [82]
T813 1617-1718 Sentence denotes SLE-associated pregnancy complications Clinical (randomized double-blind) n.a. ↓inflammation [93]
T814 1719-1805 Sentence denotes Clinical (prospective study) 6.5 mg/kg/day ↓inflammation↓risk of exacerbations [94]
T815 1806-1923 Sentence denotes Antiphospholipid syndrome Preclinical 200 μg/day ↓inflammation↓complement activation↓placental abnormalities [95]
T816 1924-1986 Sentence denotes Clinical (case report) 400 mg/day ↓vascular thrombosis [96]
T817 1987-2061 Sentence denotes Preclinical 12 μg/g/day ↓endothelial damage ↓nitric oxide synthase [97]
T818 2062-2137 Sentence denotes Preclinical 20 mg/kg/day ↓endothelial damage ↓nitric oxide synthase [98]
T819 2138-2261 Sentence denotes Clinical (observational prospective study) 200 mg/day ↓thrombotic events in patients ↓soluble tissue factor levels. [99]
T820 2262-2335 Sentence denotes Sjögren syndrome Clinical 200 mg/day ↓inflammation ↓IgG and IgA [100]
T821 2336-2396 Sentence denotes Clinical (prospective study) 400 mg/day ↓xerostomia [101]
T822 2397-2457 Sentence denotes Clinical (prospective study) 6.5 mg/kg ↓eye dryness [102]
T823 2458-2525 Sentence denotes Preclinical 50 mg/kg/day ↓ xerostomia ↓ TGF-β↓inflammation [103]
T824 2526-2598 Sentence denotes Preclinical 60 mg/kg/day ↓inflammation↓lymphocytic infiltration [104]
T825 2599-2665 Sentence denotes Diabetes Preclinical 80–120–160 mg/kg/day ↓blood glucose [105]
T826 2666-2740 Sentence denotes Preclinical 200 mg/kg/day ↓inflammatory markers↑metabolic profile [106]
T827 2741-2828 Sentence denotes Clinical (randomized, double-blinded study) 2 × 300 mg/kg ↓glycated hemoglobin [107]
T828 2829-2912 Sentence denotes Clinical (open-label longitudinal study) 6.5 mg/kg/day ↓insulin resistance [108]
T829 2913-3010 Sentence denotes Clinical (randomized, double-blinded controlled trial) 6.5 mg/kg/day ↓insulin resistance [109]
T830 3011-3104 Sentence denotes Clinical (randomized, double-blinded trial) 400 mg/day ↑glycemic and lipidic profile [110]
T831 3105-3201 Sentence denotes Cancer Preclinical 50 mg/kg ↓tumor size↓pro-tumorigenic and pro-inflammatory cytokines [111]
T832 3202-3286 Sentence denotes Cardiovascular diseases Preclinical 200 mg/kg ↓apoptosis in cardiomyocites [112]
T833 3287-3344 Sentence denotes Preclinical 200 mg/kg/day ↓triglycerides and LDL [113]
T834 3345-3408 Sentence denotes Preclinical 10 mg/kg/day ↓atherosclerosis↓inflammation [114]
T835 3409-3491 Sentence denotes Inflammatory bowel disease and colitis Preclinical 30 mg/kg ↓inflammation [74]
T836 3492-3563 Sentence denotes Pulmonary hypertension Preclinical 50 mg/kg/day ↓inflammation [115]
T837 3564-3636 Sentence denotes Endometriosis Preclinical 60 mg/kg ↓inflammation↓lesion number [116]