LitCovid-sentences  

PMC:7665480 / 6140-14362 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T53 0-7 Sentence denotes RESULTS
T54 8-48 Sentence denotes All collected data are shown in Table 1.
T55 49-104 Sentence denotes To date, 396 heart transplant patients are still alive.
T56 105-156 Sentence denotes Six patients developed active SARS-CoV-2 infection:
T57 157-248 Sentence denotes 2 of these patients died, 1 of acute respiratory distress syndrome and the other of sepsis.
T58 249-465 Sentence denotes All included patients who had heart transplants had the positive reverse transcriptase-polymerase chain reaction nasopharyngeal swab test for SARS-CoV-2 and were symptomatic with fever, cough and shortness of breath.
T59 466-578 Sentence denotes Of the 6 patients, the only female in the study presented mild symptoms and remained in self-quarantine at home.
T60 579-804 Sentence denotes The rest of our cohort was hospitalized in Northern Italy; they had moderate-to-severe symptoms, such as fever for more than 5 days, oxygen saturation below 90% requiring supportive care and signs of pneumonia on radiographs.
T61 805-813 Sentence denotes Table 1:
T62 815-884 Sentence denotes Main characteristics of the 6 heart transplant patients with COVID-19
T63 885-949 Sentence denotes Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
T64 950-962 Sentence denotes Demographics
T65 963-999 Sentence denotes  Age (years) 69 82 65 71 62 50
T66 1000-1045 Sentence denotes  Gender Male Male Male Male Male Female
T67 1046-1103 Sentence denotes  Time from heart transplant (years) 5 16 11 1 22 13
T68 1104-1117 Sentence denotes  Risk factors
T69 1118-1167 Sentence denotes   BMI (kg/m2) 22.4 23.6 24.5 25.3 32.6 21.5
T70 1168-1209 Sentence denotes   Arterial hypertension − + + + + +
T71 1210-1243 Sentence denotes   Dyslipidaemia − + + − + −
T72 1244-1281 Sentence denotes   Diabetes mellitus − − − − − −
T73 1282-1315 Sentence denotes   Former smoker + − − − − −
T74 1316-1361 Sentence denotes   Extracardiac arteriopathy − − − − − −
T75 1362-1386 Sentence denotes   COPD − − − − − −
T76 1387-1413 Sentence denotes   Stroke − − − − − −
T77 1414-1444 Sentence denotes   Malignancy − − + − − +
T78 1445-1483 Sentence denotes   GFR (ml/min) 80 40 71 82 48 85
T79 1484-1516 Sentence denotes   Previous PCI − + − − − −
T80 1517-1548 Sentence denotes   NYHA class I II I I I I
T81 1549-1584 Sentence denotes  Immunosuppressive therapy (mg/day)
T82 1585-1628 Sentence denotes   Cyclosporine 120 120 160 200 135 70
T83 1629-1674 Sentence denotes   Mycophenolate 1440 − 1440 1440 1440 −
T84 1675-1705 Sentence denotes   Everolimus − − − − − 2
T85 1706-1720 Sentence denotes COVID-19 onset
T86 1721-1741 Sentence denotes  Presenting symptoms
T87 1742-1767 Sentence denotes   Cough + + + + + +
T88 1768-1807 Sentence denotes   Shortness of breath + + + + + +
T89 1808-1835 Sentence denotes   Myalgia − + + + + +
T90 1836-1863 Sentence denotes   Anosmia − − + + + +
T91 1864-1892 Sentence denotes   Headache − − − − + +
T92 1893-1922 Sentence denotes   Sinusitis − − − − − +
T93 1923-1968 Sentence denotes   Gastrointestinal symptoms − − − − + +
T94 1969-1996 Sentence denotes  NPS test + + + + + +
T95 1997-2035 Sentence denotes  X-ray pneumonia signs + + + + −
T96 2036-2088 Sentence denotes  Fever peak (°C) 38.0 38.6 38.0 39.5 38.5 39.2
T97 2089-2123 Sentence denotes  Hospitalization + + + + + −
T98 2124-2166 Sentence denotes  SpO2 at admission (%) 91 85 97 78 85
T99 2167-2225 Sentence denotes  Worst SpO2 during hospitalization (%) 88 75 88 75 65
T100 2226-2258 Sentence denotes  Laboratory results at admission
T101 2259-2319 Sentence denotes   WBC count (cells per 109/l) 10.00 9.24 4.00 7.50 5.90
T102 2320-2361 Sentence denotes   Hb (g/dl) 10.0 13.5 12.0 13.7 13.5
T103 2362-2416 Sentence denotes   Platelets (cells per 109/l) 400 113 215 301 151
T104 2417-2477 Sentence denotes   Lymphocyte (cells per 109/l) 0.35 0.32 0.55 0.90 0.20
T105 2478-2514 Sentence denotes   CRP (mg/dl) 157 140 3.3 72 29
T106 2515-2547 Sentence denotes   PCT (ng/ml) 0.26 0.09 0 0
T107 2548-2599 Sentence denotes   Serum creatinine (mg/dl) 1.29 2.1 1.79 1.3 2
T108 2600-2636 Sentence denotes   Troponin I (ng/dl) 34 8 18 24
T109 2637-2666 Sentence denotes  LVEF (%) 55 45 70 55 50
T110 2667-2689 Sentence denotes Treatment and outcomes
T111 2690-2727 Sentence denotes  Hydroxychloroquine + + + + + −
T112 2728-2766 Sentence denotes  Lopinavir/ritonavir + − − − + −
T113 2767-2808 Sentence denotes  Corticosteroid therapy + + + + + −
T114 2809-2870 Sentence denotes  Modification of immunosuppressive therapya + + + + + −
T115 2871-2924 Sentence denotes   % Reduction of cyclosporine 40 100 60 50 40 0
T116 2925-2976 Sentence denotes   % Reduction of mycophenolate 75 0 0 50 50 0
T117 2977-3019 Sentence denotes  Antibiotics prophylaxis + + + + + +
T118 3020-3044 Sentence denotes  ICU stay + − − − +
T119 3045-3081 Sentence denotes   ICU length of stay 18 − − − 2
T120 3082-3110 Sentence denotes  High flow O2 − + − + +
T121 3111-3130 Sentence denotes  NIV − + − + +
T122 3131-3157 Sentence denotes  Intubation + − − − −
T123 3158-3172 Sentence denotes  Complications
T124 3173-3204 Sentence denotes   Respiratory − ARDS − − −
T125 3205-3249 Sentence denotes   Neurological Ischaemic stroke − − − −
T126 3250-3281 Sentence denotes   Infective Sepsis − − − −
T127 3282-3329 Sentence denotes  In-hospital length of stay 24 10 13 27 24
T128 3330-3375 Sentence denotes  Days to negative NPS testb 10 7 15 14c
T129 3376-3401 Sentence denotes  Pronation − − − + +
T130 3402-3428 Sentence denotes  Discharged − − + + +
T131 3429-3452 Sentence denotes  Dead + + − − − −
T132 3453-3535 Sentence denotes a In-hospital percentage reduction from last follow-up dose of immunosuppressant.
T133 3536-3644 Sentence denotes b Days from first positive NPS test to first seriate negative NPS test and clinical resolution of symptoms.
T134 3645-3794 Sentence denotes c The patient has been asymptomatic since receiving the results of the first NPS test, which was repeated after 14 days, per government regulations.
T135 3795-4116 Sentence denotes ARDS: acute respiratory distress syndrome; BMI: body mass index; CRP: C-reactive protein; COPD: chronic obstructive pulmonary disease; GFR: glomerular filtration rate; Hb: haemoglobin; ICU: intensive care unit; LVEF: left ventricular ejection fraction; NIV: non-invasive ventilation; NPS: naso-pharyngeal swab test; NYHA:
T136 4117-4254 Sentence denotes New York heart association; PCI: percutaneous coronary intervention; PCT: procalcitonin; SpO2: oxygen saturation; WBC: white blood cells.
T137 4256-4268 Sentence denotes Risk factors
T138 4269-4321 Sentence denotes Data collected on risk factors are shown in Table 1.
T139 4322-4434 Sentence denotes The median age was 67 years (IQR 59–74) and the median time from the heart transplant was 12 years (IQR 4–17.5).
T140 4435-4564 Sentence denotes Among the patients’ risk factors arterial hypertension was the most frequent, occurring in 83%, followed by dyslipidaemia in 50%.
T141 4565-4590 Sentence denotes Only 1 patient was obese.
T142 4591-4685 Sentence denotes The median glomerular filtration rate was 92 ml/min (IQR 79–133); no patients needed dialysis.
T143 4686-4834 Sentence denotes At the last follow-up, all patients were classified as New York Heart Association functional class I with the exception of 1 in functional class II.
T144 4835-4944 Sentence denotes One patient had a previous percutaneous coronary intervention procedure for a cardiac allograft vasculopathy.
T145 4945-5111 Sentence denotes Graft function was preserved in all patients as evidenced by the last echocardiographic follow-up with a median left ventricular ejection fraction of 56% (IQR 53–58).
T146 5112-5317 Sentence denotes Only 1 patient had a history of cellular-mediated rejection graded as moderate, 2R according to the International Society of Heart and Lung Transplantation classification of 2004, obtained in October 1997.
T147 5318-5450 Sentence denotes Immunosuppressive therapy included cyclosporine for all patients, associated with mycophenolate in 4 cases and everolimus in 1 case.
T148 5452-5468 Sentence denotes In-hospital stay
T149 5469-5500 Sentence denotes Data are summarized in Table 1.
T150 5501-5559 Sentence denotes Median in-hospital length of stay was 24 days (IQR 12–26).
T151 5560-5616 Sentence denotes Three patients were discharged home and 2 patients died.
T152 5617-5735 Sentence denotes Median oxygen saturation at admission was 85% (IQR 81–94), the worst level during hospitalization was 75% (IQR 70–88).
T153 5736-5800 Sentence denotes All hospitalized patients had signs of pneumonia on radiographs.
T154 5801-5876 Sentence denotes Troponin at admission fell consistently within the limits for all patients.
T155 5877-6077 Sentence denotes Two patients needed time in the intensive care unit and invasive ventilation; both of them were then admitted to a ward; in 1 a tracheostomy was performed to wean the patient from ventilatory support.
T156 6078-6124 Sentence denotes Pronation therapy was performed in 2 patients.
T157 6125-6200 Sentence denotes One patient needed 3 days of continuous veno-venous hemofiltration therapy.
T158 6201-6303 Sentence denotes One patient received inotropic drugs with noradrenaline at maximum doses of 0.1 mcg/kg/min for 3 days.
T159 6304-6347 Sentence denotes Extracorporeal life support was never used.
T160 6348-6441 Sentence denotes During the in-hospital stay echocardiographic monitoring was used to evaluate graft function.
T161 6442-6651 Sentence denotes With the exception of a mild reduction in the left ventricular ejection fraction in an older patient with a heart transplant that was more than 20 years old, no patients showed any changes in cardiac function.
T162 6652-6839 Sentence denotes One patient had an ischaemic stroke and a sputum culture that was positive for Pseudomonas; he required targeted antibiotics treatment; unfortunately he developed sepsis and then he died.
T163 6840-6936 Sentence denotes The other patient developed acute respiratory distress syndrome and died of respiratory failure.
T164 6938-6963 Sentence denotes Pharmacological treatment
T165 6964-7003 Sentence denotes Collected data are provided in Table 1.
T166 7004-7127 Sentence denotes During hospitalization hydroxychloroquine and broad-spectrum antibiotics for prophylaxis were administered to all patients.
T167 7128-7173 Sentence denotes Ritonavir/lopinavir were used for 2 patients.
T168 7174-7332 Sentence denotes Our adopted strategy for immunosuppressive therapy comprised a median reduction of 50% (IQR 40–80) of cyclosporine doses and 50% (IQR 13–69) of mycophenolate.
T169 7333-7439 Sentence denotes In all hospitalized patients, a 0.5–1 mg/kg/day bolus of prednisone was administered for the first 7 days.
T170 7440-7544 Sentence denotes Those intubated or in serious condition were given an equivalent intravenous dose of methylprednisolone.
T171 7545-7644 Sentence denotes Progressive tapering then followed, leading to a low maintenance dose of 5–10 mg/day at discharged.
T172 7645-7737 Sentence denotes Immunosuppressive therapy remained reduced until the first outpatient follow-up examination.
T173 7738-7846 Sentence denotes At that time, the original immunosuppressive regime was resumed and corticosteroid therapy was discontinued.
T174 7847-7884 Sentence denotes No graft rejection episodes occurred.
T175 7885-8033 Sentence denotes The patient who self-quarantined at home was treated with a broad-spectrum antibiotic and had a rapid remission of symptoms and resolution of fever.
T176 8034-8137 Sentence denotes No immunosuppressive therapy modifications were made and no anti-inflammatory agents were administered.
T177 8138-8222 Sentence denotes The results of the nasopharyngeal swab test for SARS-CoV-2 at 14 days were negative.