| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T190 |
0-147 |
Sentence |
denotes |
Conversely, we know that pharmacological interferences occurs between the antiviral drugs used to treat SARS-CoV-2 and calcineurin inhibitors [16]. |
| T191 |
148-303 |
Sentence |
denotes |
The main issue of drug–drug interactions is an increased in immunosuppressant plasma concentrations due to their shared metabolism via cytochrome-P450-3A4. |
| T192 |
304-464 |
Sentence |
denotes |
In particular, the interaction between lopinavir and calcineurin inhibitors has already been characterized as being based on suppression of cytochrome-P450-3A4. |
| T193 |
465-562 |
Sentence |
denotes |
In contrast, the interaction between hydroxychloroquine and calcineurin inhibitors is less clear. |
| T194 |
563-718 |
Sentence |
denotes |
Its metabolism via cytochrome-P450-3A4, as well as via cytochrome-P450-2C8, might theoretically increase the plasma concentration of the immunosuppressant. |
| T195 |
719-791 |
Sentence |
denotes |
Consequently, close monitoring of immunosuppressant levels is warranted. |
