LitCovid-sentences  

PMC:7665480 / 109-2085 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3 0-8 Sentence denotes Abstract
T4 10-20 Sentence denotes OBJECTIVES
T5 21-196 Sentence denotes Few anecdotal cases have been reported in the literature regarding heart transplant recipients and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
T6 197-289 Sentence denotes We report our experience with 6 patients hospitalized in Northern Italy during the outbreak.
T7 291-298 Sentence denotes METHODS
T8 299-442 Sentence denotes Of the 396 living heart transplant recipients from 1985 to 2020 included in the study, 6 patients developed the novel 2019 coronavirus disease.
T9 443-601 Sentence denotes Risk factors, last follow-up characteristics, onset presentation, in-hospital course of disease and blood examinations data were collected for these patients.
T10 603-610 Sentence denotes RESULTS
T11 611-713 Sentence denotes All patients were symptomatic and had positive results from a nasopharyngeal swab test for SARS-CoV-2.
T12 714-793 Sentence denotes Of the 6 patients, 5 were hospitalized and 1 remained self-quarantined at home.
T13 794-839 Sentence denotes Two patients died and 3 were discharged home.
T14 840-896 Sentence denotes Two patients were admittted to the intensive care unit .
T15 897-1026 Sentence denotes Immunosuppressive therapy was modified with a median reduction comprising doses that were 50% cyclosporine and 50% mycophenolate.
T16 1027-1133 Sentence denotes All patients received a medium-dose of corticosteroids as a bolus medication in addition to their therapy.
T17 1134-1229 Sentence denotes All hospitalized patients received hydroxychloroquine; 2 patients received ritonavir/lopinavir.
T18 1230-1298 Sentence denotes Broad-spectrum antibiotics for prophylaxis were administered to all.
T19 1299-1354 Sentence denotes One patient had an ischaemic stroke and died of sepsis.
T20 1356-1367 Sentence denotes CONCLUSIONS
T21 1368-1574 Sentence denotes In the absence of any strong evidence regarding the treatment of heart transplant recipients infected with SARS-CoV-2, we faced a new challenge in managing viral infection in an immunosuppressed population.
T22 1575-1784 Sentence denotes Because immunomodulation interaction with the infection seems to be crucial for developing severe forms of the disease, we managed to reduce immunosuppressive therapy by adding medium doses of corticosteroids.
T23 1785-1976 Sentence denotes Despite the limited number of affected patients, this report suggests that special considerations should be given to treating coronavirus disease in the heart transplant recipient population.