| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T284 |
0-354 |
Sentence |
denotes |
SARS-CoV-2 studies involving CD8+ T cells have shown exhaustion of the effector capacity of these cells over time by the reduction of granzyme B, perforins, and lysosome-associated membrane protein 1, also known as LAMP-1 or CD107a, described as a marker of cytotoxic cells’ degranulation and an important parameter to assess the activity of these cells. |
| T285 |
355-518 |
Sentence |
denotes |
CD8+ T cells from COVID-19 patients have a very marked activation phenotype with an increase in CD69, CD38, CD137, and CD44, especially in critically ill patients. |
| T286 |
519-742 |
Sentence |
denotes |
However, despite presenting an increase in these activation molecules, these cells also have enhanced cell exhaustion proteins, such as PD1, Tim3, CTLA-4, and TIGIT, especially in more critically ill patients (9, 154, 170). |
