| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T241 |
0-222 |
Sentence |
denotes |
During an in vitro experiment, Yang et al. (178) found that, despite being permissive to infection by SARS-CoV-2, human monocyte-derived macrophages and dendritic cells are not able to effectively produce viral replicates. |
| T242 |
223-343 |
Sentence |
denotes |
Despite their central role in pathogenesis, this may indicate that these cells are not important reservoirs for viruses. |
| T243 |
344-584 |
Sentence |
denotes |
In addition, neither of the cell types developed a response based on type II IFN, but macrophages had lower production of type I and III IFN than the control, indicating that the virus can inhibit a response mediated by these types of IFNs. |
| T244 |
585-717 |
Sentence |
denotes |
Additionally, macrophages were able to trigger an exacerbated inflammatory response with higher TNF-α, IL-8, IP10, MIP1α, and IL-1β. |
| T245 |
718-869 |
Sentence |
denotes |
Dendritic cells had not been reported to show such inflammatory phenomenon, which is due to the ability of SARS-CoV-2 to inhibit STAT1 phosphorylation. |
| T246 |
870-1106 |
Sentence |
denotes |
Such important attenuation of dendritic cell response caused by the virus may have important implications for humans to develop effective immunity, therefore, further studies should seek to better elucidate such a relevant relationship. |
