PMC:7652766 / 46665-47388 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T228 0-175 Sentence denotes Concerning monocytes, COVID-19 patients have shown an abundant circulation of CD14+ CD16+ cells, with a sharper increase in patients who developed severe respiratory syndrome.
T229 176-371 Sentence denotes This subtype of monocytes can over-secrete TNF-α, IL-1β, and IL-6 and expand quickly in systemic infections, implying that they must play an important role in the rapid defense against pathogens.
T230 372-506 Sentence denotes Controversially, these cells are the main producers of IL-10, which makes their exact function in immune responses elusive (170, 171).
T231 507-723 Sentence denotes Additionally, Dutertre et al. (172) demonstrated that CD14+ CD16+ monocytes are responsible for TNF overproduction in HIV infections and might be considered the major actor in immune hyperactivation in disease (172).