PMC:7652766 / 40631-42097 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T198 0-119 Sentence denotes IL-7 is a pleiotropic cytokine that plays an essential role in the differentiation and clonal expansion of lymphocytes.
T199 120-446 Sentence denotes Chi et al. (156) described the production of IL-7 in COVID-19 patients; when compared to healthy controls, both asymptomatic and symptomatic individuals in the acute phase show an increase in the levels of this cytokine, however convalescent individuals return to the basal state equal to that observed in healthy individuals.
T200 447-601 Sentence denotes When symptomatic individuals were stratified according to the severity of the disease, those with moderate to severe conditions had higher levels of IL-7.
T201 602-868 Sentence denotes In addition, SARS-CoV-2-specific T cells from the peripheral blood of convalescent individuals of COVID-19 show high expressions of CD127, a receptor necessary for homeostatic cell proliferation triggered by IL-7, which may be related to the recovery observed (157).
T202 869-1020 Sentence denotes Patients with a severe COVID-19 condition, on the other hand, have an increased IL-7 production, but contradictorily they also have severe lymphopenia.
T203 1021-1225 Sentence denotes Thus, we speculate that the deficiency in the expression of CD127 might occur in severely ill patients, which culminates in the deficiency of cell proliferation induced by IL-7 and consequent lymphopenia.
T204 1226-1350 Sentence denotes However, studies that seek to evaluate the expression profile of IL-7 and CD127 in COVID-19 patients need to be carried out.
T205 1351-1466 Sentence denotes In addition, the use of IL-7 as a treatment for COVID-19 patients has been evaluated and will be discussed further.