Id |
Subject |
Object |
Predicate |
Lexical cue |
T198 |
0-119 |
Sentence |
denotes |
IL-7 is a pleiotropic cytokine that plays an essential role in the differentiation and clonal expansion of lymphocytes. |
T199 |
120-446 |
Sentence |
denotes |
Chi et al. (156) described the production of IL-7 in COVID-19 patients; when compared to healthy controls, both asymptomatic and symptomatic individuals in the acute phase show an increase in the levels of this cytokine, however convalescent individuals return to the basal state equal to that observed in healthy individuals. |
T200 |
447-601 |
Sentence |
denotes |
When symptomatic individuals were stratified according to the severity of the disease, those with moderate to severe conditions had higher levels of IL-7. |
T201 |
602-868 |
Sentence |
denotes |
In addition, SARS-CoV-2-specific T cells from the peripheral blood of convalescent individuals of COVID-19 show high expressions of CD127, a receptor necessary for homeostatic cell proliferation triggered by IL-7, which may be related to the recovery observed (157). |
T202 |
869-1020 |
Sentence |
denotes |
Patients with a severe COVID-19 condition, on the other hand, have an increased IL-7 production, but contradictorily they also have severe lymphopenia. |
T203 |
1021-1225 |
Sentence |
denotes |
Thus, we speculate that the deficiency in the expression of CD127 might occur in severely ill patients, which culminates in the deficiency of cell proliferation induced by IL-7 and consequent lymphopenia. |
T204 |
1226-1350 |
Sentence |
denotes |
However, studies that seek to evaluate the expression profile of IL-7 and CD127 in COVID-19 patients need to be carried out. |
T205 |
1351-1466 |
Sentence |
denotes |
In addition, the use of IL-7 as a treatment for COVID-19 patients has been evaluated and will be discussed further. |