PMC:7652766 / 39013-39784 3 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T191 | 0-288 | Sentence | denotes | Similarly, an experimental study conducted with MERS patients indicated that type I IFN has protective activity against this infection and the blockade of its signaling resulted in delayed virus clearance, enhanced neutrophil infiltration, and impaired MERS-CoV–specific T cell responses. |
| T192 | 289-377 | Sentence | denotes | Additionally, early treatment using this type of IFN prevented fatal infections in mice. |
| T193 | 378-771 | Sentence | denotes | However, the late treatment did not cure the animals and failed to effectively inhibit virus replication, increased infiltration, and activation of monocytes, macrophages, and neutrophils in the lungs, in addition to having enhanced proinflammatory cytokine expression, which led to fatal pneumonia, indicating that type I IFN plays a central role at the very beginning of the infection (152). |