| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T113 |
0-238 |
Sentence |
denotes |
ACE2 is an enzyme belonging to the renin-angiotensin system, located on the cell surface of type II alveolar epithelial cells in the lungs and cells of other tissues, and plays a crucial role in controlling vasoactive effects in the body. |
| T114 |
239-391 |
Sentence |
denotes |
Despite their similarities, ACE and ACE2 have different substrate specificities with distinct functionalities that perform opposite actions in the body. |
| T115 |
392-587 |
Sentence |
denotes |
In brief, ACE cleaves angiotensin I to generate angiotensin II, the peptide that binds and activates angiotensin type 1 receptor (AT1R) to constrict blood vessels, thereby raising blood pressure. |
| T116 |
588-771 |
Sentence |
denotes |
In contrast, ACE2 inactivates angiotensin II (Ang-II) while generating angiotensin 1-7 (Ang-1-7), a potent heptapeptide that acts in vasodilation and attenuation of inflammation (85). |
