| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T491 |
0-128 |
Sentence |
denotes |
The action mechanism of these drugs has direct molecular effects on lysosomal activity, autophagy, and signaling pathways (347). |
| T492 |
129-327 |
Sentence |
denotes |
As antivirals, chloroquine is known to block SARS-CoV-1-infection by increasing endosomal pH required for virus entry, as well as interfering with the glycosylation of cellular receptors (351, 352). |
| T493 |
328-624 |
Sentence |
denotes |
The possible mechanism against SARS-CoV-2 is the inhibition of virus entry by altering the glycosylation of ACE2, reducing the binding efficiency between ACE2 in host cells and the S protein on the surface of the SARS-CoV-2, thus preventing the virus from binding to target cells (348, 351, 353). |
| T494 |
625-754 |
Sentence |
denotes |
In addition to a potent antiviral inhibition, the immunomodulatory activity of these drugs is well established in the literature. |
| T495 |
755-1209 |
Sentence |
denotes |
Proposed effects of chloroquine on the immune system include increasing the export of soluble antigens into the cytosol of dendritic cells, the blocking of TLR7 and TLR9 signaling, thus reconstructing CD8+ cytotoxic viral response, and inhibiting and/or reducing the production of inflammatory cytokines like IL-1, IL-6, TNF, and IFN-α (347, 354–359), which has an important role in the immunopathogenesis of COVID-19, as previously reported in item 4.1. |
