LitCovid-sentences  

PMC:7650537 / 24157-27426 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T187 0-249 Sentence denotes The kinetics of SARS-CoV-2 IgG was studied up to 165 days after positive SARS-CoV-2 PCR results by the analysis of consecutive samples from 11 patients and samples from five routine patients; four are family members of a SARS-CoV-2-infected patient.
T188 250-377 Sentence denotes The results were obtained with two IgG assays based on the N (Abbott) or the entire S (Virion-Serion) antigens as the epitopes.
T189 378-502 Sentence denotes Both tests turned out to be the most sensitive and specific assays in the validation part of our study (compare in Table 1).
T190 503-578 Sentence denotes Thereby, SARS-CoV-2-specific antibodies were detectable in all individuals.
T191 579-823 Sentence denotes While the N-based IgG assay revealed the existence of two groups of individuals, and one of them showed a rapid decrease of IgG indices within a few months, the IgG reactivity in the S protein-based assay was found to be more stable (Figure 4).
T192 824-1007 Sentence denotes This is in-line with a previous preprint [16] and could suggest that the latter test is better suited for epidemiological studies, especially when it comes to questions of prevalence.
T193 1008-1113 Sentence denotes Accordingly, the majority of SARS-CoV-2-infected patients in our study developed neutralizing antibodies.
T194 1114-1236 Sentence denotes The titers were stable during the observation period but were in a relatively low range between >1:10 and 1:80 (Figure 5).
T195 1237-1327 Sentence denotes Only three patients showed conversion from low to high SARS-CoV-2 IgG avidity (Figure S3).
T196 1328-1439 Sentence denotes The limited number of included SARS-CoV-2 patients, however, limits the informative value of the present study.
T197 1440-1686 Sentence denotes The evaluability of the simple and reproducible PRNT technique applied here may be improved by overlaying the cells with cellulose or by using specific antibodies to detect the remaining viral antigens in the cells, as reported previously [7,20].
T198 1687-1870 Sentence denotes Furthermore, the application of a modified cytopathic effect inhibition assay [30] may be useful to facilitate standardization and quantification and will be valued in future studies.
T199 1871-2025 Sentence denotes Several SARS-CoV-2-infected patients and routine patients in our study lost their SARS-CoV-2 (N)-specific IgG within a few months or could lose them soon.
T200 2026-2205 Sentence denotes These individuals can theoretically be prone to reinfection, especially since the S-specific IgG and the neutralizing antibodies are stable but only present in low indices/titers.
T201 2206-2248 Sentence denotes In a few patients, both were undetectable.
T202 2249-2373 Sentence denotes However, this view does not take into account the booster effect that can be expected in the event of renewed virus contact.
T203 2374-2441 Sentence denotes This would most likely lead to a rapid increase in antibody titers.
T204 2442-2584 Sentence denotes Accordingly, vaccine strategies against SARS-CoV-2 may need boosting to maintain sufficient neutralizing antibody titers over a long time [5].
T205 2585-2700 Sentence denotes Waning antibody titers and reinfections are known from various HCoVs mainly responsible for common colds [5,12,31].
T206 2701-2793 Sentence denotes Recently a well-documented case of an asymptomatic SARS-CoV-2 reinfection was reported [32].
T207 2794-2911 Sentence denotes In our opinion, the importance of such rare events for the progression of the temporary pandemic appears to be minor.
T208 2912-3017 Sentence denotes Nevertheless, a permanent presence of measurable SARS-CoV-2 IgG in the serum of all patients is unlikely.
T209 3018-3174 Sentence denotes This is not surprising and has also been observed in patients after infections with SARS-CoV (2002/2003) or Middle East respiratory syndrome (MERS)-CoV [5].
T210 3175-3269 Sentence denotes It does not necessarily mean that these individuals will be susceptible to severe reinfection.