LitCovid-sentences  

PMC:7647877 / 74-2515 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T4 0-157 Sentence denotes On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19).
T5 158-296 Sentence denotes Today, the scientific community is investing all the resources available to find any therapy and prevention strategies to defeat COVID-19.
T6 297-409 Sentence denotes In this context, immunonutrition can play a pivotal role in improving immune responses against viral infections.
T7 410-498 Sentence denotes Immunonutrition has been based on the concept that malnutrition impairs immune function.
T8 499-772 Sentence denotes Therefore, immunonutrition involves feeding enriched with various pharmaconutrients (Omega 3 Fatty Acids, Vitamin C, Arginine, Glutamine, Selenium, Zinc, Vitamin, E and Vitamin D) to modulate inflammatory responses, acquired immune response and to improve patient outcomes.
T9 773-963 Sentence denotes In literature, significant evidences indicate that obesity, a malnutrition state, negatively impacts on immune system functionality and on host defense, impairing protection from infections.
T10 964-1077 Sentence denotes Immunonutrients can promote patient recovery by inhibiting inflammatory responses and regulating immune function.
T11 1078-1234 Sentence denotes Immune system dysfunction is considered to increase the risk of viral infections, such as SARS-CoV-2, and was observed in different pathological situations.
T12 1235-1432 Sentence denotes Obese patients develop severe COVID-19 sequelae, due to the high concentrations of TNF-α, MCP-1 and IL-6 produced in the meantime by visceral and subcutaneous adipose tissue and by innate immunity.
T13 1433-1561 Sentence denotes Moreover, leptin, released by adipose tissue, helps to increase inflammatory milieu with a dysregulation of the immune response.
T14 1562-1751 Sentence denotes Additionally, gut microbiota plays a crucial role in the maturation, development and functions of both innate and adaptive immune system, as well as contributing to develop obese phenotype.
T15 1752-1895 Sentence denotes The gut microbiota has been shown to affect lung health through a vital crosstalk between gut microbiota and lungs, called the “gut-lung axis”.
T16 1896-2122 Sentence denotes This axis communicates through a bi-directional pathway in which endotoxins, or microbial metabolites, may affect the lung through the blood and when inflammation occurs in the lung, this in turn can affect the gut microbiota.
T17 2123-2254 Sentence denotes Therefore, the modulation of gut microbiota in obese COVID-19 patients can play a key role in immunonutrition therapeutic strategy.
T18 2255-2441 Sentence denotes This umbrella review seeks to answer the question of whether a nutritional approach can be used to enhance the immune system’s response to obesity in obese patients affected by COVID-19.