LitCovid-sentences  

PMC:7647877 / 7001-9871 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T47 0-236 Sentence denotes The binding of the cytokine to its transmembrane cell surface receptor activates an intracellular signal transduction pathway, generally a Janus kinase (Jak), which, via a kinase cascade, phosphorylates its transcription protein (STAT).
T48 237-326 Sentence denotes Phosphorylated STAT dimers and moves to the nucleus, initiating a new gene transcription.
T49 327-822 Sentence denotes Mutation of STAT1 increases susceptibility to virus infections because it is involved in various signalling pathways, including IFN-α/β, IFN- γ, IFN-l, IL-2, IL-3, IL-6, IL-9, IL-10, IL-11, IL-12, IL-15, IL-21, IL-22, IL-26 and IL-27 [10], and chemokines of several types such as C-X-C motif chemokine ligand 10 (CXCL-10), Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES)/Chemokine (C–C motif) ligand 5 (CCL-5), Monocyte Chemoattractant Protein-1 (MCP-1) [11].
T50 823-916 Sentence denotes IFN-γ promotes antigen-specific antibody production, increasing the activity of phagocytosis.
T51 917-1088 Sentence denotes In the meantime, PRRs trigger inflammatory signalling, with activation of transcription factors like nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB).
T52 1089-1456 Sentence denotes NFκB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1β), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation.
T53 1457-1564 Sentence denotes The recognition of pathogens is achieved through the presence of pattern recognition receptors (PRRs) [12].
T54 1565-1667 Sentence denotes PRRs identify the microbe-associated molecular patterns (MAMPs), and defensive responses is activated.
T55 1668-1803 Sentence denotes PRRs include Toll-like receptors (TLRs), that are able to recognize viral DNA, viral double-stranded RNA and viral single-stranded RNA.
T56 1804-1917 Sentence denotes TLRs are expressed on macrophages, dendritic cells, neutrophils, eosinophils, epithelial cells and keratinocytes.
T57 1918-2041 Sentence denotes In particular, intracellular TLR-7 and TLR-8 allow the innate recognition of the single-stranded RNA of coronaviruses [13].
T58 2042-2200 Sentence denotes Intracellular and extracellular PRRs recognized spike glycoprotein, of the coronavirus coat, starting the inflammatory process, through the NFκB pathway [14].
T59 2201-2418 Sentence denotes Moreover, Nucleotide-Binding Domain, Leucine-Rich Repeat (NLR) proteins have also been identified, and NALP3 (NACHT, LRR and PYD domains-containing protein 3) has a special function in the innate immune response [15].
T60 2419-2483 Sentence denotes The processes involved in antiviral immunity is shown in Fig. 1.
T61 2484-2557 Sentence denotes Fig. 1 Graphical representation of antiviral SARS-Coronavirus 2 immunity.
T62 2558-2560 Sentence denotes B:
T63 2561-2822 Sentence denotes B lymphocyte; CTL: cytotoxic; T lymphocyte; IFN: interferon; Ig: immunoglobulin; IL: interleukin; MHC: major histocompatibility class; NFκB: nuclear factor kappa-light- chain- enhancer of activated B cells; NK: natural killer cell; Th: helper T lymphocyte; TLR:
T64 2823-2870 Sentence denotes Toll-like receptor; TNF: tumour necrosis factor