LitCovid-sentences  

PMC:7647877 / 67585-70290 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T423 0-125 Sentence denotes Microbiota plays a crucial role in the maturation, development and functions of both innate and adaptive immune system [156].
T424 126-269 Sentence denotes The gut microbiota has been shown to affect lung health through a vital crosstalk between gut microbiota and lungs, called the “gut-lung axis”.
T425 270-498 Sentence denotes This axis communicates through a bi-directional pathway in which endotoxins, or microbial metabolites, may affect the lung through the blood and when inflammation occurs in the lung, this, in turn, can affect the gut microbiota.
T426 499-621 Sentence denotes The immunological health of the gut, primarily mediated by the microbiota, influences lung health via the “gut-lung axis”.
T427 622-795 Sentence denotes In addition, microbial communities inhabiting the mucosal surfaces of the respiratory tract also contribute towards host defense against viral respiratory infections (VRIs).
T428 796-926 Sentence denotes Acute VRIs are associated with microbial dysbiosis in these communities, thus acting the optimal functioning of the immune system.
T429 927-1167 Sentence denotes Alterations in the microbiota during influenza virus infection contributes to the pathogenesis of secondary bacterial infections, thus increasing the severity of the clinical course in the absence of appropriate immune responses [157, 158].
T430 1168-1382 Sentence denotes It is also known that alterations of the immune functions associated with chronic inflammation and related metabolic dysfunctions lead to a compromise of innate and acquired immune functions in the host [159, 160].
T431 1383-1565 Sentence denotes Moreover, chronic inflammation and the use of antibiotics are known to accompany disorders in the gut microbiota, resulting in dysbiosis and aggravation of immune dysfunctions [161].
T432 1566-1848 Sentence denotes In addition, the prevalence of comorbid conditions (including chronic lung disease, diabetes, hypertension and cardiovascular diseases) and old age predispose to infection, the development of ARDS and pneumonia, factors already observed for other infections such as influenza [162].
T433 1849-1964 Sentence denotes This point raises an interesting possibility that the new SARS-Cov-2 may also have an impact on the gut microbiota.
T434 1965-2098 Sentence denotes Indeed, several studies have shown that respiratory infections are associated with a change in the composition of the gut microbiota.
T435 2099-2248 Sentence denotes Numerous experimental and clinical observations have suggested that the gut microbiota plays a key role in the pathogenesis of sepsis and ARDS [163].
T436 2249-2472 Sentence denotes Moreover, it is known that the signals derived from the intestinal microbiota tune the cells of the immune system for pro and anti-inflammatory responses which thus influence the susceptibility to various diseases (Fig. 2).
T437 2473-2578 Sentence denotes Fig. 2 Graphical representation of immune homeostasis disequilibrium during SARS-Coronavirus 2 infection.
T438 2579-2705 Sentence denotes ARDS: acute respiratory distress syndrome; T lymphocyte; IL: interleukin; Th: helper T lymphocyte; TNF: tumour necrosis factor