| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T268 |
0-9 |
Sentence |
denotes |
Vitamin E |
| T269 |
10-183 |
Sentence |
denotes |
Vitamin E exists mainly in the form of tocopherols present in high amounts in nuts and vegetable oils, whereas tocotrienols are found predominantly in some seeds and grains. |
| T270 |
184-264 |
Sentence |
denotes |
This vitamin is involved in immunity and host susceptibility to infection [112]. |
| T271 |
265-501 |
Sentence |
denotes |
A positive association was demonstrated between plasma vitamin E and cell-mediated immune responses, while a negative association was observed among plasma vitamin E and the risk of infections in healthy adults over 60 years of age [8]. |
| T272 |
502-620 |
Sentence |
denotes |
It protects cell membranes from damage caused by free radicals and supports the integrity of epithelial barriers [79]. |
| T273 |
621-781 |
Sentence |
denotes |
Vitamin E has also been shown to regulate the maturation and functions of dendritic cells, which are important for the innate and adaptive immune systems [112]. |
| T274 |
782-1279 |
Sentence |
denotes |
The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance. |
| T275 |
1280-1426 |
Sentence |
denotes |
Indeed it improves lymphocyte proliferation and T cell mediated functions, optimizes and improves the Th1 response and suppress Th2 response [95]. |
| T276 |
1427-1577 |
Sentence |
denotes |
The role of this vitamin in the prevention of infections such as influenza has been discussed, but more controlled studies in humans are needed [114]. |
| T277 |
1578-1768 |
Sentence |
denotes |
Notably, it is accepted that vitamin E may exert its immune-enhancing effects by scavenging oxygen species to reduce oxidative stress [112] and it may induce anti-inflammatory effects [113]. |
| T278 |
1769-1953 |
Sentence |
denotes |
In particular, it appears to be an important fat-soluble antioxidant that hinders the chain reaction induced by free radicals (chain breaking effect) and protects cells from them [95]. |
