LitCovid-sentences  

PMC:7647877 / 40286-43768 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T249 0-9 Sentence denotes Vitamin D
T250 10-132 Sentence denotes Many reviews discuss the role of vitamin D and its metabolites in host immunity and susceptibility to infections [99–101].
T251 133-359 Sentence denotes Vitamin D receptors have been identified in most immune cells, of which some can also synthesize the active form of vitamin D from its precursor, therefore suggesting that might have important immunoregulatory properties [99].
T252 360-526 Sentence denotes Vitamin D is synthesized at skin level in the presence of UV-light from cholesterol and it is also taken up from the diet (fish, eggs, fortified milk, and mushrooms).
T253 527-834 Sentence denotes The active form of vitamin D, calcitriol (1,25-dihydroxy vitamin D3), formed following kidney and liver hydroxylation, is most renowned for its regulating role in calcium homeostasis and bone health status, but it has also been shown to regulate the immune system, mainly in the functioning of T-cell [102].
T254 835-1109 Sentence denotes Among the main functions of vitamin D, its ability to improve the integrity of the epithelium has mainly been observed as well as the ability to induce the synthesis of an antimicrobial peptide in epithelial cells and macrophages, thus directly improving host defense [103].
T255 1110-1319 Sentence denotes Vitamin D also promotes the differentiation of monocytes from macrophages [95], promotes the movement and phagocyability of macrophages [79], superoxide production and bacterial killing by innate immune cells.
T256 1320-1403 Sentence denotes Hence, it promotes the processing of antigen presentation by dendritic cells [104].
T257 1404-1551 Sentence denotes Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99].
T258 1552-1731 Sentence denotes It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105].
T259 1732-1939 Sentence denotes Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106].
T260 1940-2192 Sentence denotes It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104].
T261 2193-2376 Sentence denotes The 1,25-dihydroxyvitamin D3 can bind to a specific nuclear receptor (vitamin D receptor, VDR) and its role for both the innate and adaptive immune systems has been highlighted [107].
T262 2377-2481 Sentence denotes Moreover, vitamin D has been controversially discussed for its role in influenza prevention and therapy.
T263 2482-2624 Sentence denotes As shown in literature, 1,25-dihydroxyvitamin D3 undoubtedly plays a strong role as an immunomodulating agent in adaptive and innate immunity.
T264 2625-2772 Sentence denotes Different reviews have also reported that individuals with low vitamin D status have a higher risk of viral respiratory tract infections [99, 108].
T265 2773-3103 Sentence denotes Several systematic reviews show that levels of this vitamin are inversely related to respiratory tract infection [109, 110] and underlines that individuals with low vitamin D levels show an increased risk of viral tract infections, concluding that its supplementation can reduce the risk of respiratory tract infections [82, 111].
T266 3104-3294 Sentence denotes Some studies on the influenza prevention provide a negative correlation between the enhanced post-immunization vaccine and obese patients, because obesity involves a deficiency of vitamin D.
T267 3295-3482 Sentence denotes According to most authors, more randomized controlled trials with large populations are needed to explore the preventive effect of vitamin D supplementation on viral flu infections [107].