PMC:7647877 / 3806-6223 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T29 0-124 Sentence denotes The immune system protects the human body from infections by a series of pathogen (bacteria, viruses, fungi, parasites) [5].
T30 125-206 Sentence denotes A self-tolerance system prevents the immune response from damaging human tissues.
T31 207-269 Sentence denotes The immune system is always active, carrying out surveillance.
T32 270-520 Sentence denotes The defense to first exposure to the pathogen is represented by two complementary and cooperating functional divisions, the innate immune and, on the other hand, the adaptive immune response, that represents a response based on previous exposure [6].
T33 521-746 Sentence denotes The innate immune system is represented by dendritic cells, macrophages and neutrophils, with phagocytic activity, and by eosinophils, mast cells and natural killer cells, which release specific soluble antimicrobial factors.
T34 747-1021 Sentence denotes The innate immune system includes physical barriers, represented by interconnected epithelial cells (e.g. tight junctions and cellular interactions mediated by cadherin), epithelial cilia and the mucus layer of the respiratory, gastrointestinal and genitourinary epithelium.
T35 1022-1296 Sentence denotes Moreover, soluble proteins and small bioactive molecules such as complement proteins, defensins and ficolins 1-3, pro-inflammatory cytokines, chemokines, lipid mediators of inflammation, membrane-bound receptors and cytoplasmic proteins are part of the innate immune system.
T36 1297-1357 Sentence denotes Both innate and adaptive immunity is mediated by leukocytes.
T37 1358-1579 Sentence denotes Lymphocytes circulate between the blood system and the lymphatic system, passing through the peripheral lymphoid organs, which includes the spleen, tonsils, appendix, lymph nodes and gut-associated lymphoid tissue (GALT).
T38 1580-1814 Sentence denotes From a common lymphoid progenitor, four major populations of mature lymphocytes are derived, that belong to the adaptive immune system: of B lymphocytes (B cells) and T lymphocytes (T cells), natural killer (NK) cells, and NK-T cells.
T39 1815-1926 Sentence denotes T-cells can be further categorized to cytotoxic T-cells (TC cells), helper T-cells (Th) and suppressor T-cells.
T40 1927-2111 Sentence denotes The specific antigenic receptors of the adaptive response are represented by genes that code for an intact T cell receptor (TCR) and immunoglobulin genes (B cell antigen receptor; Ig).
T41 2112-2194 Sentence denotes TCR is capable of binding the antigen processed by antigen-presenting cells (APC).
T42 2195-2417 Sentence denotes Dendritic cells represent the most powerful class of APC, and express molecules of the major histocompatibility complex (MHC) of class I and II, necessary for the recognition of the antigen processed by TCR on T cells [7].