LitCovid-sentences  

PMC:7647877 / 37154-40284 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T230 0-9 Sentence denotes Vitamin C
T231 10-120 Sentence denotes The role of vitamin C in immunity and in host susceptibility to infection has been scientifically proven [92].
T232 121-281 Sentence denotes Vitamin C, in fact, is necessary for the biosynthesis of collagen and is essential for maintaining epithelial integrity and protecting against oxidative stress.
T233 282-529 Sentence denotes It protects cell membranes from damage caused by free radicals, so as to support the integrity of the epithelial barriers [79], also improves keratinocytic differentiation and lipid synthesis as well as fibroblast proliferation and migration [92].
T234 530-945 Sentence denotes It plays a role in various aspects of immunity, in fact it is involved in the proliferation, function and movement of neutrophils, monocytes and phagocytes [82] and the migration of leukocytes to sites of infection, phagocytosis and bacterial killing, in the activity of natural killer cells and in the function of T lymphocytes (especially CD8 cytotoxic T lymphocytes) and in the production of antibodies [79, 82].
T235 946-1169 Sentence denotes Vitamin C is also involved in apoptosis and elimination of depleted neutrophils from macrophage infection sites [92] and attenuates the formation of extracellular trap (NET), thus reducing the associated tissue damage [92].
T236 1170-1303 Sentence denotes Infections have a significant impact on vitamin C levels, due to the increased energy needs required by the body during inflammation.
T237 1304-1443 Sentence denotes This nutrient, in fact, promotes the proliferation of lymphocytes, with a consequent increase in the generation of antibodies [79, 85, 92].
T238 1444-1714 Sentence denotes It is well known that infections increase oxidative stress and usually activate phagocytes that release ROS, so vitamin C is a well-known antioxidant that can counteract these effects by increasing phagocytosis and ROS generation and improving microbial killing [92–94].
T239 1715-1840 Sentence denotes Furthermore, supplementation with vitamin C appears to be able to prevent and treat respiratory and systemic infections [92].
T240 1841-2018 Sentence denotes High levels of this nutrient can enhance antimicrobial effects and increase serum levels of complement proteins, also playing an important role in IFN-γ production [85, 92, 95].
T241 2019-2142 Sentence denotes Low levels of vitamin C are responsible for an increased susceptibility to severe respiratory infections such as pneumonia.
T242 2143-2333 Sentence denotes Indeed, a meta-analysis reported a significant reduction in the risk of pneumonia with vitamin C supplementation, particularly in individuals with a low dietary intake of this nutrient [96].
T243 2334-2545 Sentence denotes Vitamin C supplementation has also been demonstrated to reduce the duration and severity of upper respiratory tract infections, such as the common cold, especially in people under increased physical stress [96].
T244 2546-2650 Sentence denotes Currently, there are limited recommendations for taking vitamin C supplementation against COVID-19 [97].
T245 2651-2820 Sentence denotes Nevertheless, there is sufficient evidence to conduct several clinical trials to assess vitamin C efficacy in COVID-19 prevention and treatment (www.clinicaltrials.gov).
T246 2821-2910 Sentence denotes Previously, doses of 1–2 g/day were effective in preventing upper respiratory infections.
T247 2911-3055 Sentence denotes As those levels are not attainable through dietary sources, supplementation may be advised for those at a higher risk of respiratory infections.
T248 3056-3130 Sentence denotes Doses above 200 mg/day may not be beneficial for healthy individuals [98].