LitCovid-sentences  

PMC:7647877 / 34625-36563 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T214 0-128 Sentence denotes Vitamin A deficiency impairs barrier function, impairs immune responses and increases susceptibility to a variety of infections.
T215 129-234 Sentence denotes Furthermore, many aspects of innate immunity, in addition to barrier function, are affected by vitamin A.
T216 235-459 Sentence denotes For example, vitamin A regulates the number and function of NK cells [82], contributes to the phagocytic and oxidative activity of the macrophage burst [79] and controls the maturation of neutrophils and its deficiency [83].
T217 460-542 Sentence denotes The activity of natural killer cells is therefore reduced by vitamin A deficiency.
T218 543-695 Sentence denotes The impact of vitamin A on acquired immunity is however clear since it is involved in the development and differentiation of Th1 and Th2 cells [62, 79].
T219 696-883 Sentence denotes Moreover there is evidence that vitamin A deficiency alters the balance of Th1 and Th2 cells, decreasing the Th2 response, without affecting or, in some cases, enhancing the Th1 response.
T220 884-961 Sentence denotes This suggests that vitamin A increases the Th1 cell average in immunity [84].
T221 962-1295 Sentence denotes However, studies in several experimental models have shown how the retinoic acid metabolite of vitamin A reduces the responses of Th1-type cells (cytokines, cytokine receptors and the transcription factor T-bet, which promotes Th1), improving responses to Th2-type cells (cytokines and Th2-favoring transcription factor GATA-3) [62].
T222 1296-1438 Sentence denotes Indeed, it maintains the normal Th2 response mediated by antibodies by suppressing the production of IL-12, TNF-α and IFN-γ by Th1 cells [85].
T223 1439-1634 Sentence denotes Vitamin A appears to be important in the differentiation of regulatory T lymphocytes by suppressing Th17 differentiation, which have implications for the control of adverse immune reactions [86].
T224 1635-1814 Sentence denotes It helps regulate the production of IL-2 and the pro-inflammatory TNF-γ, which activates the phagocytic and oxidative action of the macrophages activated during inflammation [79].
T225 1815-1938 Sentence denotes It ensures the normal functioning of B lymphocytes, necessary for the generation of antibody responses to the antigen [85].