LitCovid-sentences  

PMC:7647877 / 33936-37152 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T210 0-9 Sentence denotes Vitamin A
T211 10-142 Sentence denotes The role of vitamin A and its metabolites in the immune system and host susceptibility is discussed in a series of reviews [77, 78].
T212 143-462 Sentence denotes This nutrient is involved in normal differentiation of epithelial tissue, furthermore retinoic acid is essential for imprinting T and B cells with gut-homing specificity and T array cells and IgA cells in intestinal tissues [79], thus enhancing the intestinal immune response and supporting the intestinal barrier [80].
T213 463-688 Sentence denotes Carotenoids (both provitamin A and non-provitamin A carotenoids) have immunoregulatory actions including the reduction of the toxic effects of ROS and the regulation of membrane fluidity and gap-junctional communication [81].
T214 689-817 Sentence denotes Vitamin A deficiency impairs barrier function, impairs immune responses and increases susceptibility to a variety of infections.
T215 818-923 Sentence denotes Furthermore, many aspects of innate immunity, in addition to barrier function, are affected by vitamin A.
T216 924-1148 Sentence denotes For example, vitamin A regulates the number and function of NK cells [82], contributes to the phagocytic and oxidative activity of the macrophage burst [79] and controls the maturation of neutrophils and its deficiency [83].
T217 1149-1231 Sentence denotes The activity of natural killer cells is therefore reduced by vitamin A deficiency.
T218 1232-1384 Sentence denotes The impact of vitamin A on acquired immunity is however clear since it is involved in the development and differentiation of Th1 and Th2 cells [62, 79].
T219 1385-1572 Sentence denotes Moreover there is evidence that vitamin A deficiency alters the balance of Th1 and Th2 cells, decreasing the Th2 response, without affecting or, in some cases, enhancing the Th1 response.
T220 1573-1650 Sentence denotes This suggests that vitamin A increases the Th1 cell average in immunity [84].
T221 1651-1984 Sentence denotes However, studies in several experimental models have shown how the retinoic acid metabolite of vitamin A reduces the responses of Th1-type cells (cytokines, cytokine receptors and the transcription factor T-bet, which promotes Th1), improving responses to Th2-type cells (cytokines and Th2-favoring transcription factor GATA-3) [62].
T222 1985-2127 Sentence denotes Indeed, it maintains the normal Th2 response mediated by antibodies by suppressing the production of IL-12, TNF-α and IFN-γ by Th1 cells [85].
T223 2128-2323 Sentence denotes Vitamin A appears to be important in the differentiation of regulatory T lymphocytes by suppressing Th17 differentiation, which have implications for the control of adverse immune reactions [86].
T224 2324-2503 Sentence denotes It helps regulate the production of IL-2 and the pro-inflammatory TNF-γ, which activates the phagocytic and oxidative action of the macrophages activated during inflammation [79].
T225 2504-2627 Sentence denotes It ensures the normal functioning of B lymphocytes, necessary for the generation of antibody responses to the antigen [85].
T226 2628-2814 Sentence denotes Retinoic acid appears to promote the movement of T cells to gut-associated lymphoid tissue and, interestingly, some gut-associated immune cells are able to synthesize retinoic acid [87].
T227 2815-2991 Sentence denotes Vitamin A deficiency is associated with increased morbidity and mortality in children and appears to predispose to respiratory infections, diarrhea and severe measles [88, 89].
T228 2992-3122 Sentence denotes Moreover, supplementing vitamin A in deficient children improves recovery from infectious diseases and reduces mortality [78, 90].
T229 3123-3216 Sentence denotes The Recommended Dietary Allowance (RDA) for vitamin A reports a range of 900–700 µg/day [91].