LitCovid-sentences  

PMC:7646269 / 3365-12019 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T39 0-10 Sentence denotes 3 RESULTS
T40 11-143 Sentence denotes A total of seven patients with COVID‐19 who had one or more positive respiratory cultures for Aspergillus fumigatus were identified.
T41 144-228 Sentence denotes According to the AspICU algorithm, 7 four patients were classified as putative IPA.
T42 229-526 Sentence denotes None of the patients had European Organization for Research and Treatment of Cancer/ Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) host factors, including neutropenia and prolonged use of corticosteroids.
T43 527-629 Sentence denotes Only one patient had a pre‐existing lung disease (chronic obstructive pulmonary disease in Patient 1).
T44 630-944 Sentence denotes All four patients had compatible signs (fever refractory to at least 3 days of appropriate therapy or worsening respiratory insufficiency despite appropriate antibiotic therapy and ventilatory support), host factor (glucocorticoid treatment with prednisone equivalent > 20 mg/d) and abnormal radiographic findings.
T45 945-1159 Sentence denotes Radiographic abnormalities included worsening infiltrates (Patient 1), opacities with dense consolidations (Patient 2), cavitary pneumonia (Patient 3) and diffuse interstitial and patchy hazy opacities (Patient 4).
T46 1160-1269 Sentence denotes The remaining three patients were classified as having colonisation as they lacked compatible clinical signs.
T47 1270-1360 Sentence denotes For those three patients, subsequent clinical deterioration was explained by other causes.
T48 1361-1441 Sentence denotes Clinical characteristics of the patients with putative IPA are shown in Table 1.
T49 1442-1470 Sentence denotes The median age was 79 years.
T50 1471-1605 Sentence denotes All experienced worsening respiratory status leading to invasive mechanical ventilation before the isolation of Aspergillus fumigatus.
T51 1606-1682 Sentence denotes The patients had been mechanically ventilated for a mean of 6.8 days (range:
T52 1683-1723 Sentence denotes 1‐14 days) before Aspergillus isolation.
T53 1724-1829 Sentence denotes At Aspergillus isolation, fever and leukocytosis were present in one and all four patients, respectively.
T54 1830-1902 Sentence denotes Serum galactomannan level was positive for only one patient (Patient 2).
T55 1903-1971 Sentence denotes All patients received concomitant broad‐spectrum antibiotic therapy.
T56 1972-2097 Sentence denotes Table 1 Clinical characteristics of critically ill COVID‐19‐infected patients with putative invasive pulmonary aspergillosis
T57 2098-2140 Sentence denotes Patient 1 Patient 2 Patient 3 Patient 4
T58 2141-2164 Sentence denotes Age (y) 82 79 77 77
T59 2165-2195 Sentence denotes Gender Male Male Male Male
T60 2196-2215 Sentence denotes Comorbid conditions
T61 2216-2245 Sentence denotes Hypertension No Yes No No
T62 2246-2271 Sentence denotes Diabetes No No No Yes
T63 2272-2312 Sentence denotes Coronary artery disease No Yes No No
T64 2313-2367 Sentence denotes Chronic obstructive pulmonary disease Yes No No No
T65 2368-2420 Sentence denotes History of cerebrovascular accident No Yes No No
T66 2421-2456 Sentence denotes History of cancer Yes Yes No No
T67 2457-2481 Sentence denotes Dementia No No No No
T68 2482-2606 Sentence denotes Timing of positive culture for Aspergillus fumigatus (hospital day) Day 15 and 20 Day 7, 10, and 16 Day 10 and 14 Day 10
T69 2607-2649 Sentence denotes Clinical features at Aspergillus isolation
T70 2650-2672 Sentence denotes Fever No No Yes No
T71 2673-2736 Sentence denotes Respiratory status at Aspergillus isolation IMV IMV IMV IMV
T72 2737-2916 Sentence denotes New radiographic abnormalities on chest CT or X‐ray Worsening infiltrates Opacities with dense consolidations Cavitary pneumonia Diffuse interstitial and patchy hazy opacities
T73 2917-2972 Sentence denotes White blood cell count (103/μL) 32.9 21.1 20.1 20.2
T74 2973-3016 Sentence denotes Platelet count (103/μL) 376 146 420 123
T75 3017-3062 Sentence denotes Procalcitonin (ng/mL) 0.16 0.30 3.30 9.34
T76 3063-3103 Sentence denotes Lactic acid (mmol/L) 1.0 3.6 1.6 3.7
T77 3104-3147 Sentence denotes Total bilirubin (mg/dL) 2.4 1.1 1.4 2.9
T78 3148-3192 Sentence denotes Serum creatinine (mg/dL) 2.6 3.1 1.5 4.1
T79 3193-3242 Sentence denotes Serum galactomannan NA 0.71 Negative Negative
T80 3243-3282 Sentence denotes Vasopressor support Yes Yes Yes Yes
T81 3283-3304 Sentence denotes Inpatient medications
T82 3305-3320 Sentence denotes Glucocorticoids
T83 3321-3386 Sentence denotes Cumulative dose in prednisone equivalent (mg) 932 1000 870 87
T84 3387-3444 Sentence denotes Starting date (hospital day) Day 8 Day 2 Day 2 Day 10
T85 3445-3472 Sentence denotes Duration (d) 10 10 12 3
T86 3473-3501 Sentence denotes Tocilizumab No Yes No No
T87 3502-3606 Sentence denotes Antibiotics Cefepime + Vancomycin Cefepime + Vancomycin Meropenem + Vancomycin Cefepime + Vancomycin
T88 3607-3680 Sentence denotes Antifungal therapy Voriconazole Voriconazole Voriconazole Caspofungin
T89 3681-3752 Sentence denotes Abbreviations: IMV, invasive mechanical ventilation; NA, not available.
T90 3753-3900 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T91 3901-4083 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T92 4084-4220 Sentence denotes All four patients concomitantly received glucocorticoids, with three of which were already given steroids for a mean of 6.6 days (range:
T93 4221-4267 Sentence denotes 5‐8 days) before the isolation of Aspergillus.
T94 4268-4376 Sentence denotes In the remaining one patient (patients 4), glucocorticoid therapy was administered at Aspergillus isolation.
T95 4377-4450 Sentence denotes The overall mean duration of glucocorticoid exposure was 8.5 days (range:
T96 4451-4529 Sentence denotes 3‐11 days) with a mean cumulative prednisone equivalent dose of 722 mg (range:
T97 4530-4542 Sentence denotes 87‐1000 mg).
T98 4543-4616 Sentence denotes One patient received tocilizumab after Aspergillus isolation (Patient 3).
T99 4617-4808 Sentence denotes Patient 1 was an 82‐year‐old man with a history of COPD and pharyngeal cancer who was transferred to the ICU on hospital day 3 for acute respiratory distress syndrome (ARDS) and septic shock.
T100 4809-4942 Sentence denotes He was afebrile at Aspergillus isolation on hospital day 15, but respiratory status deteriorated with increased FiO2 from 50% to 80%.
T101 4943-5001 Sentence denotes A chest radiograph showed worsening bilateral infiltrates.
T102 5002-5056 Sentence denotes He was initially treated with cefepime and vancomycin.
T103 5057-5136 Sentence denotes Voriconazole was added 3 days after the first positive culture for Aspergillus.
T104 5137-5207 Sentence denotes Leukocytosis persisted on broad‐spectrum antibiotics and voriconazole.
T105 5208-5317 Sentence denotes He developed intermittent fever with worsening respiratory status and required continued vasopressor support.
T106 5318-5455 Sentence denotes The family subsequently requested no further aggressive treatment, and he passed away 17 days after the initiation of antifungal therapy.
T107 5456-5745 Sentence denotes Patient 2 was a 79‐year‐old man with a history of hypertension, coronary artery disease, transient ischaemic attack, and renal cell carcinoma who was transferred to the ICU on hospital day 6 for worsening acute hypoxemic respiratory failure requiring intubation and mechanical ventilation.
T108 5746-5867 Sentence denotes He was afebrile and had been on non‐invasive ventilation (NIV) for 6 days before Aspergillus isolation on hospital day 7.
T109 5868-5941 Sentence denotes Respiratory culture grew Aspergillus fumigatus and Staphylococcus aureus.
T110 5942-6078 Sentence denotes A chest CT showed dense bilateral lower lobe consolidations, multifocal ground‐glass opacities, pneumomediastinum and pneumopericardium.
T111 6079-6133 Sentence denotes He was initially treated with cefepime and vancomycin.
T112 6134-6206 Sentence denotes Voriconazole was started at the second positive culture for Aspergillus.
T113 6207-6296 Sentence denotes A repeat chest CT showed similar findings together with worsening ground‐glass opacities.
T114 6297-6487 Sentence denotes Despite subsequent treatment with meropenem, vancomycin, and voriconazole, he continued to deteriorate with persistent leukocytosis, worsening respiratory status, and multiorgan dysfunction.
T115 6488-6550 Sentence denotes He expired 13 days after the initiation of antifungal therapy.
T116 6551-6701 Sentence denotes Patient 3 was a 77‐year‐old man with no past medical history who was admitted to the ICU for acute hypoxemic respiratory failure requiring intubation.
T117 6702-6767 Sentence denotes He developed a fever at Aspergillus isolation on hospital day 10.
T118 6768-6807 Sentence denotes Respiratory status had remained stable.
T119 6808-6863 Sentence denotes He was initially treated with meropenem and vancomycin.
T120 6864-6919 Sentence denotes Fever persisted for 4 days, and voriconazole was added.
T121 6920-7189 Sentence denotes A chest CT showed bilateral patchy ground‐glass opacities, bilateral mid to lower lung zone predominant consolidative opacities, bilateral lower lobe cavitary lesions, the largest of which is seen within the right lung base and one of which contains an air‐fluid level.
T122 7190-7233 Sentence denotes He was then treated with voriconazole only.
T123 7234-7280 Sentence denotes Fever and leukocytosis subsided within 6 days.
T124 7281-7522 Sentence denotes A repeat chest CT after 2 weeks of voriconazole showed improved bilateral ground‐glass opacities, stable to mildly improved cavitary pneumonia within the bilateral lower lobes, and a new cavitary lesion within the subpleural left lower lobe.
T125 7523-7688 Sentence denotes The subsequent course was complicated by intravenous catheter‐related thrombophlebitis with Staphylococcus epidermidis bacteremia, which was treated with vancomycin.
T126 7689-7881 Sentence denotes He had a protracted hospital course with persistent metabolic encephalopathy, chronic respiratory failure required tracheostomy, multiorgan dysfunction and subsequent Staphylococcus pneumonia.
T127 7882-7998 Sentence denotes Due to a lack of improvement, the family requested comfort care, and he expired after 1 month of antifungal therapy.
T128 7999-8173 Sentence denotes Patient 4 was a 77‐year‐old man with a history of type 2 diabetes mellitus who was transferred to the ICU on hospital day 8 for worsening acute hypoxemic respiratory failure.
T129 8174-8368 Sentence denotes He had been on NIV for 8 days and on cefepime and vancomycin until respiratory status further deteriorated, which required intubation and transfer to the ICU 2 days before Aspergillus isolation.
T130 8369-8429 Sentence denotes He was afebrile at Aspergillus isolation on hospital day 10.
T131 8430-8486 Sentence denotes Chest radiographs showed diffuse ground‐glass opacities.
T132 8487-8550 Sentence denotes Caspofungin was started together with meropenem and vancomycin.
T133 8551-8654 Sentence denotes He continued to deteriorate with multiorgan dysfunction and expired after 3 days of antifungal therapy.