LitCovid-sentences  

PMC:7646269 / 12021-16759 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T134 0-13 Sentence denotes 4 DISCUSSION
T135 14-123 Sentence denotes Reports of pulmonary aspergillosis complicating severe COVID‐19 required mechanical ventilation are emerging.
T136 124-252 Sentence denotes 5 , 6 Most patients did not have underlying immunocompromising conditions, as observed in patients with ARDS due to influenza.
T137 253-449 Sentence denotes 2 Detailed data from patients who presented in the first waves of COVID‐19 pandemic are needed to define the incidence and clinical features of COVID‐19‐associated pulmonary aspergillosis (CAPA).
T138 450-570 Sentence denotes 8 We herein describe the clinical characteristics of four cases of critically ill COVID‐19 complicated by putative IPA.
T139 571-672 Sentence denotes Early diagnosis of IPA is critical but challenging in mechanically ventilated patients with COVID‐19.
T140 673-795 Sentence denotes Bronchoscopy and transbronchial biopsy are rarely performed given the risk of complications and transmission of the virus.
T141 796-878 Sentence denotes Further, pneumonia due to SARS‐CoV‐2 may obscure the radiological findings of IPA.
T142 879-1066 Sentence denotes Consolidation is commonly seen in both COVID‐19 and superimposing pulmonary aspergillosis, and any new radiological signs could be obscured by background bilateral ground‐glass opacities.
T143 1067-1213 Sentence denotes Systemic inflammatory markers are almost always elevated with severe COVID‐19, which make them less useful to diagnose secondary fungal infection.
T144 1214-1471 Sentence denotes While it has been suggested that a low procalcitonin level may indicate a high likelihood for invasive fungal infection in critically ill patients with clinical signs of sepsis, 9 the procalcitonin level was elevated in only two patients with putative IPA.
T145 1472-1728 Sentence denotes At our institution, fungal cultures are routinely performed on bronchoscopy specimens and other respiratory specimens as clinically indicated; consequently, it is plausible there were instances of Aspergillus respiratory infection that were not identified.
T146 1729-1796 Sentence denotes Aspergillus infection can be seen in construction‐related clusters.
T147 1797-1968 Sentence denotes 10 While there was some construction at our institution during the first wave of COVID‐19, it was physically remote from the units where all of the cases were identified.
T148 1969-2113 Sentence denotes Further, there were no instances of isolating Aspergillus from any patients without the diagnosis of COVID‐19 within or around the study period.
T149 2114-2246 Sentence denotes For research purposes, EORTC/MSG Consensus Group have proposed definitions of proven, probable and possible invasive fungal disease.
T150 2247-2441 Sentence denotes 11 However, these consensus definitions are much less useful for immunocompetent patients in the ICU, as the diagnosis of probable or possible IPA requires the presence of classic host factors.
T151 2442-2639 Sentence denotes We used the AspICU criteria, which is an algorithm for diagnosing IPA in the ICU patients with positive Aspergillus endotracheal aspirate cultures, 7 to distinguish putative IPA from colonisation.
T152 2640-2783 Sentence denotes However, the performance characteristics of the algorithm for COVID‐19 patients have not been validated with autopsy or postmortem biopsy data.
T153 2784-2856 Sentence denotes Serum galactomannan was positive in only one patient in our case series.
T154 2857-2993 Sentence denotes Serum galactomannan is more specific for invasive aspergillosis than beta‐D‐glucan but has poor sensitivity in non‐neutropenic patients.
T155 2994-3110 Sentence denotes 12 Combining three case series of CAPA, only three (13%) out of 23 patients had positive serum galactomannan level.
T156 3111-3316 Sentence denotes 5 , 6 , 13 The less frequently elevated serum galactomannan levels might simply reflect colonisation rather than infection or suggest that angioinvasive pulmonary infection is a rare phenomenon in CAPA.
T157 3317-3404 Sentence denotes In any case, the diagnostic value of serum galactomannan for CAPA seems less promising.
T158 3405-3539 Sentence denotes All the patients with putative IPA died in our consecutive cases, suggesting the grave prognosis of critically ill patients with CAPA.
T159 3540-3719 Sentence denotes On the other hand, Alanio et al reported no significant difference in mortality between IPA and non‐IPA patients in a report of eight COVID‐19‐infected patients with putative IPA.
T160 3720-3845 Sentence denotes 6 Further data from multi‐institutional series are needed to clearly characterise the potential impact on mortality of CAPA.
T161 3846-4076 Sentence denotes Although dexamethasone was recently shown to decrease 28‐day mortality in mechanically ventilated patients with COVID‐19, 14 the majority of our cases received much higher doses of glucocorticoids than what was proven beneficial.
T162 4077-4260 Sentence denotes Since one of the potential sequelae of COVID‐19 is secondary fungal infections as our cases demonstrated, vigilance for secondary infections will be needed to reduce adverse outcomes.
T163 4261-4557 Sentence denotes Clinicians should have a high index of suspicion for CAPA when a critically ill patient with COVID‐19 in the ICU develops further respiratory decompensation, fevers or new or worsening radiographic abnormalities of the lungs, particularly if there is no response to empiric antibacterial therapy.
T164 4558-4738 Sentence denotes It is important to obtain a respiratory culture for fungal pathogens and a serum galactomannan level in these settings to attempt to identify this ominous complication of COVID‐19.