| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T312 |
0-112 |
Sentence |
denotes |
First, we made an attempt to assign possible functions to the 78 identified DEPs using GO functional annotation. |
| T313 |
113-468 |
Sentence |
denotes |
This tool is an internationally standardized system for gene function classification, which provides a dynamic, updated, controlled vocabularies or ontologies and can well interpret the characteristics of target genes and gene products in various organisms.41 The proteins of our interest involving in different biological functions are listed as follows. |
| T314 |
469-632 |
Sentence |
denotes |
Five type I interferon (IFN)-inducible proteins, ISG15, OAS1, Mx1, IFIT1, and IFIT3, were clustered into the BP category associated with the immune system process. |
| T315 |
633-803 |
Sentence |
denotes |
Another five cell cycle-regulating proteins, ERCC6L, NME7, NFYB, FOSL1, and CTDP1, were also classified into the BP category but associated with the reproductive process. |
| T316 |
804-1170 |
Sentence |
denotes |
The nucleolar remodeling complex-constituting protein BAZ2A and the calcium ion binding protein secretagogin were clustered into the same CC category related to synapse.42,43 The apolipoprotein binding protein VLDLR and the cell cycle control and progression-related protein CDK9 were also divided into the CC category but associated with the macromolecular complex. |
| T317 |
1171-1374 |
Sentence |
denotes |
In addition, three proteins, FOSL1, NUP37, and DDX55, were annotated to be associated with structural molecule activity, transporter activity and catalytic activity, respectively, within the MF category. |
| T318 |
1375-1670 |
Sentence |
denotes |
For further functional annotation of the DEPs, we took a step further by performing COG function classification, which is a widely used tool for analyzing the function and evolution of proteins at the genome scale.44,45 We discovered that most of the DEPs were assigned new biological functions. |
| T319 |
1671-2186 |
Sentence |
denotes |
For example, the immune system process-related proteins ISG15, OAS1, IFIT1, and IFIT3 categorized by GO functional annotation, were assigned to be involved in signal transduction mechanisms within the COG function classification; the proteins DDX55, SMARCA2, and ERCC6L belonging to three different GO categories were categorized into the same COG category—chromatin structure and dynamics; and the proteins NFYB, FOSL1, and CTDP1 belonging to the same GO category were still in the same COG category—transcription. |
| T320 |
2187-2348 |
Sentence |
denotes |
The aforementioned findings suggested that there exist slight discrepancies in the classification of some proteins between the GO and COG functional annotations. |
| T321 |
2349-2482 |
Sentence |
denotes |
This phenomenon is not unanticipated because the two functional annotation tools are based on different classification criteria.41,44 |
